Sampath Kumar H, Herrmann L, Tsogoeva S (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Book Volume: 30
Article Number: 127514
Journal Issue: 23
DOI: 10.1016/j.bmcl.2020.127514
Structural hybridization of preclinically and clinically validated pharmacologically active molecules has emerged as a promising tool to develop new generations of safe and highly efficient drug candidates against various diseases including microbial infections, virus infections and cancer. Strategies of drug-drug combinations have been adopted to generate hybrid conjugates of many clinically used drugs, designed to address inherent problems associated with these drugs. Thus, the design of hybrids was aimed to achieve higher efficacy through possible multi-target interactions, selective delivery of the drug to the site of action with the aim to improve bioavailability, alleviate toxicity and circumvent drug resistances. In this review article, we summarize the progress made in recent years in the rapidly growing field of drug discovery, focusing on the rationality of the hybrid design with particular emphasis on the linker architecture, which plays a crucial role in the overall success of a hybrid drug.
APA:
Sampath Kumar, H., Herrmann, L., & Tsogoeva, S. (2020). Structural hybridization as a facile approach to new drug candidates. Bioorganic & Medicinal Chemistry Letters, 30(23). https://doi.org/10.1016/j.bmcl.2020.127514
MLA:
Sampath Kumar, Halmuthur, Lars Herrmann, and Svetlana Tsogoeva. "Structural hybridization as a facile approach to new drug candidates." Bioorganic & Medicinal Chemistry Letters 30.23 (2020).
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