Imaging of OA – From disease modification to clinical utility

Hayashi D, Roemer F, Eckstein F, Samuels J, Guermazi A (2020)

Publication Type: Journal article, Review article

Publication year: 2020

Journal

Best Practice & Research in Clinical Rheumatology Elsevier

Article Number: 101588

DOI: 10.1016/j.berh.2020.101588

Abstract

Multiple disease-modifying osteoarthritis drug (DMOAD) trials were done in the last two decades, but no pharmacological agent has yet been approved by regulatory agencies as an effective therapy to date. Given the fact that we have seen the recent discontinuation of several late-stage drug development trials, a careful strategy is needed in formulating a plan for a successful DMOAD trial – including the various roles of imaging. This narrative review article will summarize how imaging is utilized in osteoarthritis from the perspective of disease modification to clinical utility. We will describe how semi-quantitative and quantitative magnetic resonance imaging approaches have been deployed in DMOAD trials. We will then review the utility of musculoskeletal ultrasound in research and clinical settings. Finally, novel hybrid positron emission tomography/MRI techniques and current research using artificial intelligence will be discussed, focusing on original research. Older publications are included for the discussion of the previous DMOAD trials and other relevant topics where deemed appropriate.

Authors with CRIS profile

Frank Roemer Institute of Radiology

Involved external institutions

Boston Medical Center (BMC) US United States (USA) (US) New York University (NYU) US United States (USA) (US) State University of New York at Albany (UNY Albany / UAlbany) US United States (USA) (US) Paracelsus Medizinische Privatuniversität AT Austria (AT)

How to cite

APA:

Hayashi, D., Roemer, F., Eckstein, F., Samuels, J., & Guermazi, A. (2020). Imaging of OA – From disease modification to clinical utility. Best Practice & Research in Clinical Rheumatology. https://doi.org/10.1016/j.berh.2020.101588

MLA:

Hayashi, Daichi, et al. "Imaging of OA – From disease modification to clinical utility." Best Practice & Research in Clinical Rheumatology (2020).

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