Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development
Herzog W, Mueller K, Huisken J, Stainier DYR (2009)
Publication Type: Journal article
Publication year: 2009
Journal
Book Volume: 104
Pages Range: 1260-1266
Journal Issue: 11
DOI: 10.1161/CIRCRESAHA.108.191718
Abstract
In a recent genetic screen, we identified mutations in genes important for vascular development and maintenance in zebrafish (Jin et al. Dev Biol. 2007;307:29-42). Thirty-two mutations at the adrasteia (adr) locus cause a pronounced dilatation of the aortic arch vessels as well as aberrant patterning of the hindbrain capillaries and, to a lesser extent, intersomitic vessels. This dilatation of the aortic arch vessels does not appear to be caused by increased cell proliferation but is dependent on vascular endothelial growth factor (Vegf) signaling. By positional cloning, we isolated seryl-tRNA synthetase (sars) as the gene affected by the adr mutations. Small interfering RNA knockdown experiments in human umbilical vein endothelial cell cultures indicate that SARS also regulates endothelial sprouting. These analyses of zebrafish and human endothelial cells reveal a new noncanonical function of Sars in endothelial development. © 2009 American Heart Association, Inc.
Authors with CRIS profile
Involved external institutions
University of California San Francisco (UCSF)
United States (USA) (US)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine
Germany (DE)
United States (USA) (US)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine
Germany (DE)
How to cite
APA:
Herzog, W., Mueller, K., Huisken, J., & Stainier, D.Y.R. (2009). Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development. Circulation Research, 104(11), 1260-1266. https://doi.org/10.1161/CIRCRESAHA.108.191718
MLA:
Herzog, Wiebke, et al. "Genetic evidence for a noncanonical function of seryl-tRNA synthetase in vascular development." Circulation Research 104.11 (2009): 1260-1266.
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