Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues
Sugden WW, Meissner R, Aegerter-Wilmsen T, Tsaryk R, Leonard EV, Bussmann J, Hamm MJ, Herzog W, Jin Y, Jakobsson L, Denz C, Siekmann AF (2017)
Publication Type: Journal article
Publication year: 2017
Journal
Book Volume: 19
Pages Range: 653-665
Journal Issue: 6
DOI: 10.1038/ncb3528
Abstract
The hierarchical organization of properly sized blood vessels ensures the correct distribution of blood to all organs of the body, and is controlled via haemodynamic cues. In current concepts, an endothelium-dependent shear stress set point causes blood vessel enlargement in response to higher flow rates, while lower flow would lead to blood vessel narrowing, thereby establishing homeostasis. We show that during zebrafish embryonic development increases in flow, after an initial expansion of blood vessel diameters, eventually lead to vessel contraction. This is mediated via endothelial cell shape changes. We identify the transforming growth factor beta co-receptor endoglin as an important player in this process. Endoglin mutant cells and blood vessels continue to enlarge in response to flow increases, thus exacerbating pre-existing embryonic arterial-venous shunts. Together, our data suggest that cell shape changes in response to biophysical cues act as an underlying principle allowing for the ordered patterning of tubular organs.
Authors with CRIS profile
Involved external institutions
Max-Planck-Institut für molekulare Biomedizin / Max Planck Institute for Molecular Biomedicine
Germany (DE)
Karolinska Institute
Sweden (SE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
University of Zurich / Universität Zürich (UZH)
Switzerland (CH)
Germany (DE)
Karolinska Institute
Sweden (SE)
Westfälische Wilhelms-Universität (WWU) Münster
Germany (DE)
University of Zurich / Universität Zürich (UZH)
Switzerland (CH)
How to cite
APA:
Sugden, W.W., Meissner, R., Aegerter-Wilmsen, T., Tsaryk, R., Leonard, E.V., Bussmann, J.,... Siekmann, A.F. (2017). Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues. Nature Cell Biology, 19(6), 653-665. https://doi.org/10.1038/ncb3528
MLA:
Sugden, Wade W., et al. "Endoglin controls blood vessel diameter through endothelial cell shape changes in response to haemodynamic cues." Nature Cell Biology 19.6 (2017): 653-665.
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