γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism

Petermann F, Rothhammer V, Claussen MC, Haas JD, Blanco LR, Heink S, Prinz I, Hemmer B, Kuchroo VK, Oukka M, Korn T (2010)

Publication Type: Journal article

Publication year: 2010

Journal

Immunity Elsevier

Book Volume: 33

Pages Range: 351-363

Journal Issue: 3

DOI: 10.1016/j.immuni.2010.08.013

Abstract

Mice that lack interleukin-23 (IL-23) are resistant to T cell-mediated autoimmunity. Although IL-23 is a maturation factor for T helper 17 (Th17) cells, a subset of γδ T cells expresses the IL-23 receptor (IL-23R) constitutively. Using IL-23R reporter mice, we showed that γδ T cells were the first cells to respond to IL-23 during experimental autoimmune encephalomyelitis (EAE). Although γδ T cells produced Th17 cell-associated cytokines in response to IL-23, their major function was to prevent the development of regulatory T (Treg) cell responses. IL-23-activated γδ T cells rendered αβ effector T cells refractory to the suppressive activity of Treg cells and also prevented the conversion of conventional T cells into Foxp3+ Treg cells in vivo. Thus, IL-23, which by itself has no direct effect on Treg cells, is able to disarm Treg cell responses and promote antigen-specific effector T cell responses via activating γδ T cells. © 2010 Elsevier Inc.

Authors with CRIS profile

Veit Rothhammer

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School DE Germany (DE) Technische Universität München (TUM) DE Germany (DE) Harvard University US United States (USA) (US) University of Washington US United States (USA) (US)

How to cite

APA:

Petermann, F., Rothhammer, V., Claussen, M.C., Haas, J.D., Blanco, L.R., Heink, S.,... Korn, T. (2010). γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism. Immunity, 33(3), 351-363. https://doi.org/10.1016/j.immuni.2010.08.013

MLA:

Petermann, Franziska, et al. "γδ T Cells Enhance Autoimmunity by Restraining Regulatory T Cell Responses via an Interleukin-23-Dependent Mechanism." Immunity 33.3 (2010): 351-363.

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