Type IV secretion systems and their effectors in bacterial pathogenesis
Backert S, Meyer TF (2006)
Publication Type: Journal article, Review article
Publication year: 2006
Journal
Book Volume: 9
Pages Range: 207-217
Journal Issue: 2
DOI: 10.1016/j.mib.2006.02.008
Abstract
Type IV secretion systems (T4SSs) are membrane-associated transporter complexes used by various bacteria to deliver substrate molecules to a wide range of target cells. T4SSs are involved in horizontal DNA transfer to other bacteria and eukaryotic cells, in DNA uptake from or release into the extracellular milieu, in toxin secretion and in the injection of virulence factors into eukaryotic host target cells by several mammalian pathogens. Rapid progress has been made towards defining the structures and functions of T4SSs, identifying the translocated effector molecules and elucidating the mechanisms by which the effectors subvert eukaryotic cellular processes during infection. These findings have had an important impact on our understanding of how these pathogens manipulate host cell functions to trigger bacterial uptake, facilitate intracellular growth and suppress defence mechanisms, thus facilitating bacterial colonization and disease development. © 2005 Elsevier Ltd. All rights reserved.
Authors with CRIS profile
Involved external institutions
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Max-Planck-Institut für Infektionsbiologie / Max Planck Institute for Infection Biology
Germany (DE)
Germany (DE)
Max-Planck-Institut für Infektionsbiologie / Max Planck Institute for Infection Biology
Germany (DE)
How to cite
APA:
Backert, S., & Meyer, T.F. (2006). Type IV secretion systems and their effectors in bacterial pathogenesis. Current Opinion in Microbiology, 9(2), 207-217. https://doi.org/10.1016/j.mib.2006.02.008
MLA:
Backert, Steffen, and Thomas F. Meyer. "Type IV secretion systems and their effectors in bacterial pathogenesis." Current Opinion in Microbiology 9.2 (2006): 207-217.
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