Tyrosine-phosphorylated bacterial effector proteins: The enemies within
Backert S, Selbach M (2005)
Publication Type: Journal article, Review article
Publication year: 2005
Journal
Book Volume: 13
Pages Range: 476-484
Journal Issue: 10
DOI: 10.1016/j.tim.2005.08.002
Abstract
The tyrosine phosphorylation of proteins has a central role during signal transduction in eukaryotes. Recent progress shows that tyrosine phosphorylation is also a common feature of several effector proteins translocated by bacterial type III and type IV secretion systems. The involvement of these secretion systems in disease development is exemplified by a variety of pathogenic processes: pedestal formation (Tir of EPEC and Citrobacter), cell scattering (CagA of Helicobacter), invasion (Tarp of Chlamydia) and possibly proinflammatory responses and cell proliferation (BepD-F of Bartonella). The discovery that different bacterial pathogens use this common strategy to subvert host-cell function suggests that more examples will soon emerge. © 2005 Elsevier Ltd. All rights reserved.
Authors with CRIS profile
Involved external institutions
Otto-von-Guericke-Universität Magdeburg
Germany (DE)
Max-Planck-Institut für Infektionsbiologie / Max Planck Institute for Infection Biology
Germany (DE)
Germany (DE)
Max-Planck-Institut für Infektionsbiologie / Max Planck Institute for Infection Biology
Germany (DE)
How to cite
APA:
Backert, S., & Selbach, M. (2005). Tyrosine-phosphorylated bacterial effector proteins: The enemies within. Trends in Microbiology, 13(10), 476-484. https://doi.org/10.1016/j.tim.2005.08.002
MLA:
Backert, Steffen, and Matthias Selbach. "Tyrosine-phosphorylated bacterial effector proteins: The enemies within." Trends in Microbiology 13.10 (2005): 476-484.
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