Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity

Stojičkov M, Sturm S, Čobeljić B, Pevec A, Jevtović M, Scheitler A, Radanović D, Senft L, Turel I, Andjelković K, Miehlich M, Meyer K, Ivanovic-Burmazovic I (2020)

Publication Type: Journal article

Publication year: 2020

Journal

DOI: 10.1002/ejic.202000415

Abstract

We have synthesized and characterized Co(II) (1), Zn(II) (2), Fe(III) (3) and Cu(II) (4) complexes of 2,2'-[2,6-pyridinediylbis(ethylidyne-1-hydrazinyl-2-ylidene)]bis[N,N,N-trimethyl-2-oxoethanaminium] dichloride (H2LCl2) by NMR, IR, and X-Band EPR spectroscopy, respectively, as well as by single-crystal X-ray structural analysis. H2LCl2 belongs to the class of diacetylpyridine bis(hydrazone) ligands and bears two positively charged quaternary ammonium functionalities. The complexes 1–3 possess a pentagonal-bipyramidal geometry, whereas 4 has square-pyramidal geometry. Redox reactivity and SOD activity of the complexes was studied by means of electrochemical measurements in aqueous-buffer and DMF or DMSO solutions, respectively, as well as by stopped-flow measurements. Complexes 1–3 do not have SOD activity, whereas 4 exhibits a high catalytic rate constant for the superoxide dismutation, kcat = 1.73 × 10⁷ m^–1 s^–1 (in MOPS buffer solution of pH = 7.4). The results were discussed in terms of complex redox potentials, electrostatic interactions and their spatial distribution, kinetic lability of metal centers, and stability of peroxo intermediates, respectively.

Authors with CRIS profile

Involved external institutions

University of Ljubljana (UL) / Univerza v Ljubljani Slovenia (SI) University of Belgrade / Универзитет у Београду Serbia (RS)

How to cite

APA:

Stojičkov, M., Sturm, S., Čobeljić, B., Pevec, A., Jevtović, M., Scheitler, A.,... Ivanovic-Burmazovic, I. (2020). Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity. European Journal of Inorganic Chemistry. https://doi.org/10.1002/ejic.202000415

MLA:

Stojičkov, Marko, et al. "Cobalt(II), Zinc(II), Iron(III), and Copper(II) Complexes Bearing Positively Charged Quaternary Ammonium Functionalities: Synthesis, Characterization, Electrochemical Behavior, and SOD Activity." European Journal of Inorganic Chemistry (2020).

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