Incorporation of bioactive glasses containing Mg, Sr, and Zn in electrospun PCL fibers by using benign solvents

Sergi R, Cannillo V, Boccaccini AR, Liverani L (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Applied Sciences MDPI

Book Volume: 10

Article Number: 5530

Journal Issue: 16

DOI: 10.3390/app10165530

Abstract

Poly(ε-caprolactone) (PCL) and PCL/bioactive glass composite fiber mats were produced by electrospinning technique. To improve cell adhesion and proliferation (i) 45S5, (ii) a bioactive glass containing strontium and magnesium oxides, and (iii) a bioactive glass containing zinc oxide were separately added to the starting PCL solution before electrospinning. A good incorporation of bioactive glass particles in PCL electrospun mats was confirmed by SEM and FTIR analyses. Bioactivity was evaluated by immersion of PCL mats and PCL/bioactive glass electrospun fiber mats in simulated body fluid (SBF). Bone murine stromal cells (ST-2) were employed in WST-8 assay to assess cell viability, cell morphology, and proliferation. The results showed that the presence of bioactive glass particles in the fibers enhances cell adhesion and proliferation compared to neat PCL mats. Furthermore, PCL/bioactive glass electrospun mats showed higher wound-healing rate (measured as cell migration rate) in vitro compared to neat PCL electrospun mats. Therefore, the characteristics of the PCL matrix combined with biological properties of bioactive glasses make PCL/bioactive glass composite ideal candidate for biomedical application.

Authors with CRIS profile

Aldo Boccaccini Lehrstuhl für Werkstoffwissenschaften (Biomaterialien) Liliana Liverani Lehrstuhl für Werkstoffwissenschaften (Biomaterialien)

Involved external institutions

Università degli Studi di Modena e Reggio Emilia (UNIMORE) IT Italy (IT)

How to cite

APA:

Sergi, R., Cannillo, V., Boccaccini, A.R., & Liverani, L. (2020). Incorporation of bioactive glasses containing Mg, Sr, and Zn in electrospun PCL fibers by using benign solvents. Applied Sciences, 10(16). https://doi.org/10.3390/app10165530

MLA:

Sergi, Rachele, et al. "Incorporation of bioactive glasses containing Mg, Sr, and Zn in electrospun PCL fibers by using benign solvents." Applied Sciences 10.16 (2020).

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