Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)
Kornhuber J, Tripal P, Gulbins E, Mühlbacher M (2013)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2013
Journal
Edited Volumes: Sphingolipids: Basic Science and Drug Development
Pages Range: 169-186
ISBN: 9783709113677
DOI: 10.1007/978-3-7091-1368-4_9
Abstract
Sphingolipids are not only structural components of biological membranes, but also play an important role in cellular signalling and, thus, are involved in cell proliferation and differentiation but also stress and cell death. It is therefore of great clinical relevance to define inhibitors of the enzymes involved in sphingolipid metabolism. Here, we describe the state of the art of functional inhibitors of the acid sphingomyelinase. The acid sphingomyelinase converts sphingomyelin to ceramide, a compound often involved in cell stress. We describe the structural and physicochemical properties, the distribution, the pharmacokinetics, the pharmocodynamics and the clinical use of direct and functional inhibitors of the acid sphingomyelinase.
Authors with CRIS profile
Johannes Kornhuber
Lehrstuhl für Psychiatrie und Psychotherapie
Philipp Tripal
Lehrstuhl für Psychiatrie und Psychotherapie
Markus Mühlbacher
Naturwissenschaftliche Fakultät
Involved external institutions
Germany (DE)How to cite
APA:
Kornhuber, J., Tripal, P., Gulbins, E., & Mühlbacher, M. (2013). Functional Inhibitors of Acid Sphingomyelinase (FIASMAs). In Erich Gulbins; Irina Petrache (Eds.), Sphingolipids: Basic Science and Drug Development. (pp. 169-186).
MLA:
Kornhuber, Johannes, et al. "Functional Inhibitors of Acid Sphingomyelinase (FIASMAs)." Sphingolipids: Basic Science and Drug Development. Ed. Erich Gulbins; Irina Petrache, 2013. 169-186.
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