IsAPOE epsilon 4 associated with cognitive performance in early MS?

Engel S, Graetz C, Salmen A, Muthuraman M, Toenges G, Ambrosius B, Bayas A, Berthele A, Heesen C, Klotz L, Kuempfel T, Linker R, Meuth SG, Paul F, Stangel M, Tackenberg B, Bergh FT, Tumani H, Weber F, Wildemann B, Zettl UK, Antony G, Bittner S, Groppa S, Hemmer B, Wiendl H, Gold R, Zipp F, Lill CM, Luessi F (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Book Volume: 7

Journal Issue: 4

DOI: 10.1212/NXI.0000000000000728

Abstract

Objective To assess the impact ofAPOEpolymorphisms on cognitive performance in patients newly diagnosed with clinically isolated syndrome (CIS) or relapsing-remitting MS (RRMS). Methods This multicenter cohort study included 552 untreated patients recently diagnosed with CIS or RRMS according to the 2005 revised McDonald criteria. The single nucleotide polymorphisms rs429358 (epsilon 4) and rs7412 (epsilon 2) of theAPOEhaplotype were assessed by allelic discrimination assays.Cognitive performance was evaluated using the 3-second paced auditory serial addition test and the Multiple Sclerosis Inventory Cognition (MUSIC). Sum scores were calculated to approximate the overall cognitive performance and memory-centered cognitive functions. The impact of theAPOEcarrier status on cognitive performance was assessed using multiple linear regression models, also including demographic, clinical, MRI, and lifestyle factors. Results APOE epsilon 4 homozygosity was associated with lower overall cognitive performance, whereas no relevant association was observed forAPOE epsilon 4 heterozygosity orAPOE epsilon 2 carrier status. Furthermore, higher disability levels, MRI lesion load, and depressive symptoms were associated with lower cognitive performance. Patients consuming alcohol had higher test scores than patients not consuming alcohol. Female sex, lower disability, and alcohol consumption were associated with better performance in the memory-centered subtests of MUSIC, whereas no relevant association was observed forAPOEcarrier status. Conclusion Along with parameters of a higher disease burden,APOE epsilon 4 homozygosity was identified as a potential predictor of cognitive performance in this large cohort of patients with CIS and early RRMS.

Authors with CRIS profile

Involved external institutions

Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) Ludwig-Maximilians-Universität (LMU) Germany (DE) Ruprecht-Karls-Universität Heidelberg Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE) Universität Rostock Germany (DE) Technische Universität München (TUM) Germany (DE) Ruhr-Universität Bochum (RUB) Germany (DE) Westfälische Wilhelms-Universität (WWU) Münster Germany (DE) Max-Planck-Institut für Psychiatrie (Deutsche Forschungsanstalt für Psychiatrie) Germany (DE) Universität Ulm Germany (DE) Philipps-Universität Marburg Germany (DE) Universitätsklinikum Augsburg Germany (DE) Charité - Universitätsmedizin Berlin Germany (DE) Universität Bern Switzerland (CH) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Universität Leipzig Germany (DE)

How to cite

APA:

Engel, S., Graetz, C., Salmen, A., Muthuraman, M., Toenges, G., Ambrosius, B.,... Luessi, F. (2020). IsAPOE epsilon 4 associated with cognitive performance in early MS? Neurology, Neuroimmunology and Neuroinflammation, 7(4). https://doi.org/10.1212/NXI.0000000000000728

MLA:

Engel, Sinah, et al. "IsAPOE epsilon 4 associated with cognitive performance in early MS?" Neurology, Neuroimmunology and Neuroinflammation 7.4 (2020).

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