Early postoperative seizures (EPS) in patients undergoing brain tumour surgery

Ersoy TF, Ridwan S, Grote A, Coras R, Simon M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 13674

Journal Issue: 1

DOI: 10.1038/s41598-020-70754-z

Abstract

Early postoperative seizures (EPS) are a common complication of brain tumour surgery. This paper investigates risk factors, management and clinical relevance of EPS. We retrospectively analysed the occurrence of EPS, clinical and laboratory parameters, imaging and histopathological findings in a cohort of 679 consecutive patients who underwent craniotomies for intracranial tumours between 2015 and 2017. EPS were observed in 34/679 cases (5.1%), with 14 suffering at least one generalized seizure. Patients with EPS had a worse postoperative Karnofsky performance index (KPI; with EPS, KPI < 70 vs. 70–100: 11/108, 10.2% vs. 23/571, 4.0%; p = 0.007). Preoperative seizure history was a predictor for EPS (none vs. 1 vs. ≥ 2 seizures: p = 0.037). Meningioma patients had the highest EPS incidence (10.1%, p < 0.001). Cranial imaging identified a plausible cause in most cases (78.8%). In 20.6%, EPS were associated with a persisting new neurological deficit that could not otherwise be explained. 34.6% of the EPS patients had recurrent seizures within one year. EPS require an emergency work-up. Multiple EPS and recurrent seizures are frequent, which indicates that EPS may also reflect a more chronic condition i.e. epilepsy. EPS are often associated with persisting neurological worsening.

Authors with CRIS profile

Roland Coras Institute of Neuropathology

Involved external institutions

Evangelisches Klinikum Bethel DE Germany (DE)

How to cite

APA:

Ersoy, T.F., Ridwan, S., Grote, A., Coras, R., & Simon, M. (2020). Early postoperative seizures (EPS) in patients undergoing brain tumour surgery. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-70754-z

MLA:

Ersoy, Tunc Faik, et al. "Early postoperative seizures (EPS) in patients undergoing brain tumour surgery." Scientific Reports 10.1 (2020).

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