Arterial Hypertension in Children
Rascher W, Paech C (2020)
Publication Type: Book chapter / Article in edited volumes
Publication year: 2020
Journal
Publisher: Springer
Edited Volumes: Pediatric Pharmacotherapy
Series: Handbook of Experimental Pharmacology
City/Town: Cham
Book Volume: 261
Pages Range: 193-208
DOI: 10.1007/164_2020_359
Abstract
Pharmacological treatment of arterial hypertension in children is mainly based on individual experience, but there is evidence that blocking the angiotensin system reduces systolic and diastolic blood when compared to placebo, and these drugs are safe to use for a short duration, also in children under 6 years of age. Blocking the angiotensin system either by angiotensin-converting enzyme inhibitors or by antagonizing the angiotensin 1 receptor is effective, but did not display a consistent dose-response relationship with escalating doses, but the effective doses are known. Calcium channel antagonists are effective antihypertensives in children, but the evidence is limited. Based on small-sized studies, beta-blockers modestly reduce systolic blood pressure, but have no significant effect on diastolic blood pressure compared to placebo. They act in combination to antagonize reflex tachycardia induced by vasodilators. The most commonly used antihypertensive agents are safe to use in short-term studies.
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Germany (DE)How to cite
APA:
Rascher, W., & Paech, C. (2020). Arterial Hypertension in Children. In Wieland Kiess, Matthias Schwab, Johannes van den Anker (Eds.), Pediatric Pharmacotherapy. (pp. 193-208). Cham: Springer.
MLA:
Rascher, Wolfgang, and Christian Paech. "Arterial Hypertension in Children." Pediatric Pharmacotherapy. Ed. Wieland Kiess, Matthias Schwab, Johannes van den Anker, Cham: Springer, 2020. 193-208.
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