Influence of Family History of Breast or Ovarian Cancer on Pathological Complete Response and Long-Term Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy

Wunderle M, Häberle L, Hein A, Jud S, Lux MP, Hack C, Emons J, Heindl F, Nabieva N, Löhberg C, Schulz-Wendtland R, Hartmann A, Beckmann M, Fasching P, Gaß P (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Breast Care Karger

DOI: 10.1159/000507475

Abstract

Purpose: In breast cancer, a pathological complete response (pCR) has been described as generally resulting in a favorable prognosis. However, there are subgroups, such as patients with a mutation in BRCA1 or BRCA2,in which the effect of pCR on the prognosis is suspected to be weaker. Patients with a family history of breast and/or ovarian cancer may therefore react differently in relation to pCR and prognosis, and this is investigated in this study. Patients and Methods: Breast cancer patients were identified from a clinical breast cancer registry. The study subjects had been treated with neoadjuvant chemotherapy from 2001 to 2018 and their pathological and clinical information as well as medical family history were available. They were considered to have a positive family history if they had at least 1 first-degree relative with breast and/or ovarian cancer. Multivariate logistic regression analyses were performed to study the association between family history, pCR (ypT0; ypN0), and disease-free survival (DFS). Results: Of 1,480 patients, 228 (15.4%) had a positive family history. The pCR rates were 24.9% in all patients, and 24.4% and 27.6% in those without/with a family history, respectively. Family history was not associated with a higher pCR rate (adjusted odds ratio [OR] 1.23; 95% confidence interval [CI] 0.85-1.76; p = 0.27) or a different disease-free survival (DFS; adjusted hazard ratio [HR] 1.15; 95% CI 0.88-1.52; p = 0.30). pCR did not affect the prognosis differently in relation to family history. Conclusions: In this retrospective analysis, family history was not associated with pCR and DFS. pCR improved survival, independently of family history.

Authors with CRIS profile

Marius Wunderle Department of Obstetrics and Gynaecology Alexander Hein Department of Obstetrics and Gynaecology Sebastian Jud Department of Obstetrics and Gynaecology Carolin Hack Medizinische Fakultät Felix Heindl Department of Obstetrics and Gynaecology Naiba Nabieva Department of Obstetrics and Gynaecology Christian Löhberg Medizinische Fakultät Arndt Hartmann Lehrstuhl für Allgemeine Pathologie und Pathologische Anatomie Matthias Beckmann Lehrstuhl für Geburtshilfe und Frauenheilkunde Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Paul Gaß Department of Obstetrics and Gynaecology

Involved external institutions

St. Josefs-Krankenhaus Salzkotten DE Germany (DE)

How to cite

APA:

Wunderle, M., Häberle, L., Hein, A., Jud, S., Lux, M.P., Hack, C.,... Gaß, P. (2020). Influence of Family History of Breast or Ovarian Cancer on Pathological Complete Response and Long-Term Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy. Breast Care. https://doi.org/10.1159/000507475

MLA:

Wunderle, Marius, et al. "Influence of Family History of Breast or Ovarian Cancer on Pathological Complete Response and Long-Term Prognosis in Breast Cancer Patients Treated with Neoadjuvant Chemotherapy." Breast Care (2020).

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