The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target

Binder J, Shadkchan Y, Osherov N, Krappmann S (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Frontiers in Microbiology Frontiers Media

Book Volume: 11

Article Number: 1383

DOI: 10.3389/fmicb.2020.01383

Abstract

The identification of cellular targets for antifungal compounds is a cornerstone for the development of novel antimycotics, for which a significant need exists due to increasing numbers of susceptible patients, emerging pathogens, and evolving resistance. For the human pathogenic mold Aspergillus fumigatus, the causative agent of the opportunistic disease aspergillosis, only a limited number of established targets and corresponding drugs are available. Among several targets that were postulated from a variety of experimental approaches, the conserved thioredoxin reductase (TrxR) activity encoded by the trxR gene was assessed in this study. Its essentiality could be confirmed following a conditional TetOFF promoter replacement strategy. Relevance of the trxR gene product for oxidative stress resistance was revealed and, most importantly, its requirement for full virulence of A. fumigatus in two different models of infection resembling invasive aspergillosis. Our findings complement the idea of targeting the reductase component of the fungal thioredoxin system for antifungal therapy.

Authors with CRIS profile

Jasmin Binder Professur für Klinische Mikrobiologie und Immunologie Sven Krappmann Professur für Klinische Mikrobiologie und Immunologie

Involved external institutions

Tel Aviv University IL Israel (IL)

How to cite

APA:

Binder, J., Shadkchan, Y., Osherov, N., & Krappmann, S. (2020). The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target. Frontiers in Microbiology, 11. https://doi.org/10.3389/fmicb.2020.01383

MLA:

Binder, Jasmin, et al. "The Essential Thioredoxin Reductase of the Human Pathogenic Mold Aspergillus fumigatus Is a Promising Antifungal Target." Frontiers in Microbiology 11 (2020).

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