Simon B, Uslu U (2020)
Publication Type: Journal article
Publication year: 2020
DOI: 10.1111/exd.14131
After the recent success and approvals of chimeric antigen receptor (CAR) T cells in haematological malignancies, its efficacy is currently evaluated in a broad spectrum of tumor entities including melanoma. However, severe and potentially life-threatening side effects like cytokine release syndrome, neurologic toxicities, and the competing risk of morbidity and mortality from the treatment itself are still a major limiting factor in the current CAR T-cell landscape. In addition, especially in solid tumors, the lack of ideal target antigens to avoid on-target/off-tumor toxicities also restricts its use. While various groups are working on strategies to boost CAR T-cell efficacy, mechanisms to increase engineered T-cell safety should not move out of focus. Thus, the aim of this article is to summarize and to discuss current and potential future strategies and mechanisms to increase CAR T-cell safety in order to enable the wide use of this promising approach in melanoma and other tumor entities.
APA:
Simon, B., & Uslu, U. (2020). Fasten the seat belt: Increasing safety of CAR T-cell therapy. Experimental Dermatology. https://doi.org/10.1111/exd.14131
MLA:
Simon, Bianca, and Ugur Uslu. "Fasten the seat belt: Increasing safety of CAR T-cell therapy." Experimental Dermatology (2020).
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