Inert macrocyclic Eu3+ complex with affirmative paraCEST features
Gambino T, Laura V, Perez-Lourido P, Esteban-Gomez D, Zaiß M, Platas-Iglesias C, Angelovski G (2020)
Publication Type: Journal article
Publication year: 2020
Journal
Book Volume: 7
Pages Range: 2274-2286
Journal Issue: 12
DOI: 10.1039/c9qi01612k
Abstract
We report on a macrocyclic platform based on an 18-membered macrocycle that forms kinetically highly inert paramagnetic complexes and possesses an excellent outlook for the development of bioresponsive paraCEST (paramagnetic chemical exchange saturation transfer) contrast agents. The investigated europium(III) chelate is non-hydrated and contains four amide groups, each possessing two paramagnetically shifted proton resonances distant from bulk water. The X-ray crystal structure and solution studies indicate that the metal ion is ten-coordinated, being directly bound to the six N atoms of the macrocycle and the four amide O atoms of the pendant arms. The complex presents an excellent inertness with respect to dissociation, being stable under a variety of harsh conditions, including highly acidic and basic media or elevated temperatures. The amide protons are in slow-to-intermediate exchange with bulk water, which gives rise to the generation of a strong CEST effect at low probe concentration and saturation powers (similar to 25% at 5 mM, B-1 = 5 mu T, 37 degrees C). We demonstrate the potential of this platform for mapping pH in its microenvironment and foresee potential for the development of diverse paraCEST probes and sensors.
Authors with CRIS profile
Involved external institutions
University of A Coruña / Universidade da Coruña
Spain (ES)
University of Vigo / Universidade de Vigo
Spain (ES)
Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics
Germany (DE)
Spain (ES)
University of Vigo / Universidade de Vigo
Spain (ES)
Max-Planck-Institut für biologische Kybernetik / Max Planck Institute for Biological Cybernetics
Germany (DE)
How to cite
APA:
Gambino, T., Laura, V., Perez-Lourido, P., Esteban-Gomez, D., Zaiß, M., Platas-Iglesias, C., & Angelovski, G. (2020). Inert macrocyclic Eu3+ complex with affirmative paraCEST features. Inorganic Chemistry Frontiers, 7(12), 2274-2286. https://doi.org/10.1039/c9qi01612k
MLA:
Gambino, Tanja, et al. "Inert macrocyclic Eu3+ complex with affirmative paraCEST features." Inorganic Chemistry Frontiers 7.12 (2020): 2274-2286.
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