Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease

Sekula P, Tin A, Schultheiss UT, Baid-Agrawal S, Mohney RP, Steinbrenner I, Yu B, Luo S, Boerwinkle E, Eckardt KU, Coresh J, Grams ME, Kӧttgen A (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 10018

Journal Issue: 1

DOI: 10.1038/s41598-020-66334-w

Abstract

Higher serum 6-bromotryptophan has been associated with lower risk of chronic kidney disease (CKD) progression, implicating mechanisms beyond renal clearance. We studied genetic determinants of urine 6-bromotryptophan and its association with CKD risk factors and incident end-stage kidney disease (ESKD) in 4,843 participants of the German Chronic Kidney Disease (GCKD) study. 6-bromotryptophan was measured from urine samples using mass spectrometry. Patients with higher levels of urine 6-bromotryptophan had higher baseline estimated glomerular filtration rate (eGFR, p < 0.001). A genome-wide association study of urine 6-bromotryptophan identified two significant loci possibly related to its tubular reabsorption, SLC6A19, and its production, ERO1A, which was also associated with serum 6-bromotryptophan in an independent study. The association between urine 6-bromotryptophan and time to ESKD was assessed using Cox regression. There were 216 ESKD events after four years of follow-up. Compared with patients with undetectable levels, higher 6-bromotryptophan levels were associated with lower risk of ESKD in models unadjusted and adjusted for ESKD risk factors other than eGFR (

Authors with CRIS profile

Kai-Uwe Eckardt Department of Medicine 4 – Nephrology and Hypertension

Involved external institutions

Metabolon, Inc. US United States (USA) (US) Johns Hopkins University (JHU) US United States (USA) (US) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset SE Sweden (SE) Albert-Ludwigs-Universität Freiburg DE Germany (DE) University of Texas Health Science Center at Houston (UTHealth) US United States (USA) (US) University of Mississippi Medical Center US United States (USA) (US)

How to cite

APA:

Sekula, P., Tin, A., Schultheiss, U.T., Baid-Agrawal, S., Mohney, R.P., Steinbrenner, I.,... Kӧttgen, A. (2020). Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-66334-w

MLA:

Sekula, Peggy, et al. "Urine 6-Bromotryptophan: Associations with Genetic Variants and Incident End-Stage Kidney Disease." Scientific Reports 10.1 (2020).

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