Pujales Paradela R (2019)
Publication Status: Published
Publication Type: Journal article, Original article
Publication year: 2019
Publisher: AMER CHEMICAL SOC
Book Volume: 58
Pages Range: 7571-7583
Journal Issue: 11
DOI: 10.1021/acs.inorgchem.9b00869
We present a detailed study of the lanthanide(III) complexes with cyclen-based ligands containing phenylacetamide pendants that incorporate CF3 group(s) at different distances from the metal ion. The complexes exhibit square-antiprismatic coordination in solution, as demonstrated by analysis of the Yb3+-induced paramagnetic shifts and the X-ray structure of the [YbL3] complex. Luminescence lifetime measurements and a detailed H-1 and O-17 relaxometric characterization confirmed the presence of an inner-sphere H2O molecule. The Tm3+ complexes provide chemical-exchange saturation-transfer response upon saturation at the frequency of the amide protons. A F-19 relaxation study provided accurate estimates of the Ln center dot center dot center dot F distances that were used to rationalize the efficiency of the complexes as F-19 magnetic resonance imaging (MRI) probes, which was tested in vitro using MRI phantom studies.
APA:
Pujales Paradela, R. (2019). Lanthanide Complexes with H-1 paraCEST and F-19 Response for Magnetic Resonance Imaging Applications. Inorganic Chemistry, 58(11), 7571-7583. https://dx.doi.org/10.1021/acs.inorgchem.9b00869
MLA:
Pujales Paradela, Rosa. "Lanthanide Complexes with H-1 paraCEST and F-19 Response for Magnetic Resonance Imaging Applications." Inorganic Chemistry 58.11 (2019): 7571-7583.
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