Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers

Stickel F, Lutz P, Buch S, Nischalke HD, Silva I, Rausch V, Fischer J, Weiss KH, Gotthardt D, Rosendahl J, Marot A, Elamly M, Krawczyk M, Casper M, Lammert F, Buckley TWM, Mcquillin A, Spengler U, Eyer F, Vogel A, Marhenke S, Von Felden J, Wege H, Sharma R, Atkinson S, Franke A, Nehring S, Moser V, Schafmayer C, Spahr L, Lackner C, Stauber RE, Canbay A, Link A, Valenti L, Grove J, Aithal GP, Marquardt JU, Fateen W, Zopf S, Dufour JF, Trebicka J, Datz C, Deltenre P, Mueller S, Berg T, Hampe J, Morgan MY (2020)

Publication Type: Journal article

Publication year: 2020

Journal

DOI: 10.1002/hep.30996

Abstract

Background and Aims Carriage of rs738409:G in patatin-like phospholipase domain containing 3 (PNPLA3) is associated with an increased risk for developing alcohol-related cirrhosis and hepatocellular carcinoma (HCC). Recently, rs72613567:TA in hydroxysteroid 17-beta dehydrogenase 13 (HSD17B13) was shown to be associated with a reduced risk for developing alcohol-related liver disease and to attenuate the risk associated with carriage of PNPLA3 rs738409:G. This study explores the risk associations between these two genetic variants and the development of alcohol-related cirrhosis and HCC.

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Involved external institutions

Geneva University Hospitals / Hôpitaux universitaires de Genève (HUG) Switzerland (CH) Université de Lausanne (UNIL) Switzerland (CH) Christian-Albrechts-Universität zu Kiel Germany (DE) Medizinische Hochschule Hannover (MHH) / Hannover Medical School Germany (DE) University College London (UCL) United Kingdom (GB) Ruhr-Universität Bochum (RUB) Germany (DE) Goethe-Universität Frankfurt am Main Germany (DE) Universitätsklinikum Heidelberg Germany (DE) Rheinische Friedrich-Wilhelms-Universität Bonn Germany (DE) Universitätsklinikum Leipzig Germany (DE) Paracelsus Medizinische Privatuniversität Austria (AT) Nottingham University Hospitals United Kingdom (GB) Universitätsklinikum Hamburg-Eppendorf (UKE) Germany (DE) Imperial College London / The Imperial College of Science, Technology and Medicine United Kingdom (GB) Università degli studi di Milano Italy (IT) Universität des Saarlandes (UdS) Germany (DE) Technische Universität Dresden Germany (DE) Universitätsspital Zürich (USZ) Switzerland (CH) Universitätsklinikum Halle (Saale) Germany (DE) Universität Bern Switzerland (CH) Technische Universität München (TUM) Germany (DE) Johannes Gutenberg-Universität Mainz (JGU) Germany (DE)

How to cite

APA:

Stickel, F., Lutz, P., Buch, S., Nischalke, H.D., Silva, I., Rausch, V.,... Morgan, M.Y. (2020). Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers. Hepatology. https://doi.org/10.1002/hep.30996

MLA:

Stickel, Felix, et al. "Genetic Variation in HSD17B13 Reduces the Risk of Developing Cirrhosis and Hepatocellular Carcinoma in Alcohol Misusers." Hepatology (2020).

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