Microbiota and metabolites in rheumatic diseases
Tong Y, Marion T, Schett G, Luo Y, Liu Y (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Article Number: 102530
DOI: 10.1016/j.autrev.2020.102530
Abstract
As a gigantic community in the human body, the microbiota exerts pleiotropic roles in human health and disease ranging from digestion and absorption of nutrients from food, defense against infection of pathogens, to regulation of immune system development and immune homeostasis. Recent advances in “omics” studies and bioinformatics analyses have broadened our insights of the microbiota composition of the inner and other surfaces of the body and their interactions with the host. Apart from the direct contact of microbes at the mucosal barrier, metabolites produced or metabolized by the gut microbes can serve as important immune regulators or initiators in a wide variety of diseases, including gastrointestinal diseases, metabolic disorders and systemic rheumatic diseases. This review focuses on the most recent understanding of how the microbiota and metabolites shape rheumatic diseases. Studies that explore the mechanistic interplay between microbes, metabolites and the host could thereby provide clues for novel methods in the diagnosis, therapy, and prevention of rheumatic diseases.
Authors with CRIS profile
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China (CN)How to cite
APA:
Tong, Y., Marion, T., Schett, G., Luo, Y., & Liu, Y. (2020). Microbiota and metabolites in rheumatic diseases. Autoimmunity Reviews. https://doi.org/10.1016/j.autrev.2020.102530
MLA:
Tong, Yanli, et al. "Microbiota and metabolites in rheumatic diseases." Autoimmunity Reviews (2020).
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