A degenerative medial meniscus retains some protective effect against osteoarthritis-induced subchondral bone changes

Mitton G, Engelke K, Uk S, Laredo JD, Chappard C (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Bone Reports Elsevier

Book Volume: 12

Article Number: 100271

DOI: 10.1016/j.bonr.2020.100271

Abstract

Objectives: The objective was to estimate the impact of the meniscus on cartilage and subchondral bone in knee osteoarthritis (OA). Methods: In a sample of 46 knee specimens (26 females), 13 (7 females) were classified as OA according to the Kellgren-Lawrence classification. Outerbridge and meniscal grading were performed. Using micro-computed tomography images, we analyzed the cartilage thickness, subchondral plate thickness and micro-architecture of trabecular subchondral bone at different depths and in two different locations of the medial tibial plateau: one peripheral (PER) covered by the meniscus and one central (CENT) uncovered by the meniscus. Results: Uncoverage by the meniscus was associated with bone sclerosis, defined as higher bone volume to total volume (BV/TV), higher trabecular number, thicker trabeculae with lower spacing, and anisotropy and a more plate-like architecture. The protective effect of meniscal coverage was observed in the uppermost 5 to 6 mm of the subchondral bone. As compared with normal knees, knees with OA showed significantly higher bone sclerosis (P <0.05–0.001) at the PER location, but only BV/TV (P=0.03) and trabecular number (P=0.02) differed between OA and non-OA knees at the CENT location uncovered by meniscus. Conclusions: OA results showed a partial dedifferentiation of the subchondral bone micro-architecture between PER and CENT locations probably due to menisci that still retain some of their protective effects on the subchondral bone.

Authors with CRIS profile

Klaus Engelke Lehrstuhl für Medizinische Physik und Mikrogewebetechnik (IMP)

Involved external institutions

National Institute for Health and Medical Research / Institut national de la santé et de la recherche médicale (INSERM) FR France (FR)

How to cite

APA:

Mitton, G., Engelke, K., Uk, S., Laredo, J.D., & Chappard, C. (2020). A degenerative medial meniscus retains some protective effect against osteoarthritis-induced subchondral bone changes. Bone Reports, 12. https://doi.org/10.1016/j.bonr.2020.100271

MLA:

Mitton, G., et al. "A degenerative medial meniscus retains some protective effect against osteoarthritis-induced subchondral bone changes." Bone Reports 12 (2020).

BibTeX: Download