Respiratory infections regulated blood cells IFN-β-PD-L1 pathway in pediatric asthma

Kölle J, Haag P, Vuorinen T, Kiefer A, Rauh M, Zimmermann T, Papadopoulos NG, Finotto S (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Immunity, Inflammation and Disease Wiley

DOI: 10.1002/iid3.307

Abstract

Background: Respiratory infections, in general, and rhinovirus infection specifically are the main reason for asthma exacerbation in children and programmed cell death protein 1 ligand (PD-L1) expression inhibits T cell responses. Objective: Could the interferon (IFN) type I expression in peripheral blood mononuclear cells (PBMCs) improve disease exacerbation in pediatric asthma?. Results: Here we found increased level of PD-L1 messenger RNA (mRNA) in total blood cells isolated from preschool children with virus-induced asthma, with lower percentage of forced expiratory volume in 1 second and with high serum levels of the C-reactive-protein. Conclusions and Clinical Relevance: These data indicate that, in the presence of infection in the airways of preschool children, worse asthma is associated with induced PD-L1 mRNA expression in blood cells. Further, type I IFN, IFN-β, a cytokine that is involved in the clearance of infections, was found to be associated with a better lung function in asthmatic children. These data suggest that improving peripheral blood IFN type I expression in PBMCs in pediatric asthma could improve disease exacerbation due to suppressing PD-L1 expression in blood cells.

Authors with CRIS profile

Julia Kölle Department of Molecular Pneumology Patricia Haag Professur für Molekulare Pneumologie Manfred Rauh Department of Paediatrics and Adolescent Medicine Theodor Zimmermann Medizinische Fakultät Susetta Neurath-Finotto Department of Molecular Pneumology

Involved external institutions

University of Turku / Turun yliopisto FI Finland (FI) National and Kapodistrian University of Athens GR Greece (GR)

How to cite

APA:

Kölle, J., Haag, P., Vuorinen, T., Kiefer, A., Rauh, M., Zimmermann, T.,... Finotto, S. (2020). Respiratory infections regulated blood cells IFN-β-PD-L1 pathway in pediatric asthma. Immunity, Inflammation and Disease. https://doi.org/10.1002/iid3.307

MLA:

Kölle, Julia, et al. "Respiratory infections regulated blood cells IFN-β-PD-L1 pathway in pediatric asthma." Immunity, Inflammation and Disease (2020).

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