Kaposi's sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo.

Stürzl M, Brandstetter H, Roth WK (1992)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 1992

Journal

Aids Research and Human Retroviruses Mary Ann Liebert

Book Volume: 8

Pages Range: 1753-63

Journal Issue: 10

DOI: 10.1089/aid.1992.8.1753

Abstract

The ultrastructural features and the gene expression pattern of Kaposi's sarcoma (KS) spindle cells in vivo suggest that KS is a tumor of the mixed cell type. The expression pattern of cytokines and cytokine receptors in the tumor lesion, together with the results obtained from in vitro characterization of KS-derived cells, provide evidence that paracrine mechanisms of growth factor action are important for the maintenance of KS. The reports on virus infection of KS cells suggest an indirect role of virus infection in the induction of KS, most likely mediated by immunostimulation and subsequent production of cytokines.

Authors with CRIS profile

Michael Stürzl Professur für Molekulare und Experimentelle Chirurgie

Involved external institutions

Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry DE Germany (DE)

How to cite

APA:

Stürzl, M., Brandstetter, H., & Roth, W.K. (1992). Kaposi's sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo. Aids Research and Human Retroviruses, 8(10), 1753-63. https://doi.org/10.1089/aid.1992.8.1753

MLA:

Stürzl, Michael, Heinz Brandstetter, and W K Roth. "Kaposi's sarcoma: a review of gene expression and ultrastructure of KS spindle cells in vivo." Aids Research and Human Retroviruses 8.10 (1992): 1753-63.

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