Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-alpha therapy: a case report.

Monini P, Sirianni MC, Franco M, Vincenzi L, Topino S, Goletti D, Leone P, Leone P, Chiozzini C, Nicastri E, Andreoni M, Borduagni O, Sgadari C, Rezza G, Stürzl M, Ensoli B (2001)

Publication Status: Published

Publication Type: Journal article, Report

Publication year: 2001

Journal

Clinical Infectious Diseases Oxford University Press (OUP): Policy A1 - Oxford Open Option C

Book Volume: 33

Pages Range: 1782-5

Journal Issue: 10

DOI: 10.1086/323982

Abstract

A human immunodeficiency virus-negative woman with severe classic Kaposi's sarcoma, idiopathic leukopenia, and massive spread of human herpesvirus 8 (HHV-8) in circulating cells showed stable disease remission in response to systemic interferon-alpha treatment that was accompanied by increased CD3(+) and CD4(+) T cell numbers and complete clearance of HHV-8 from the circulation. These results suggest a direct relationship between HHV-8 clearance from blood and regression of Kaposi's sarcoma and are consistent with the in vitro inhibitory effects of interferon-alpha on HHV-8 infection.

Authors with CRIS profile

Michael Stürzl Professur für Molekulare und Experimentelle Chirurgie

Involved external institutions

Italian National Health Institute / Istituto Superiore di Sanità (ISS) IT Italy (IT) Università degli studi "La Sapienza" IT Italy (IT) Università degli Studi di Roma 'Tor Vergata' IT Italy (IT) Policlinico Tor Vergata IT Italy (IT)

How to cite

APA:

Monini, P., Sirianni, M.C., Franco, M., Vincenzi, L., Topino, S., Goletti, D.,... Ensoli, B. (2001). Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-alpha therapy: a case report. Clinical Infectious Diseases, 33(10), 1782-5. https://doi.org/10.1086/323982

MLA:

Monini, Paolo, et al. "Clearance of human herpesvirus 8 from blood and regression of leukopenia-associated aggressive classic Kaposi's sarcoma during interferon-alpha therapy: a case report." Clinical Infectious Diseases 33.10 (2001): 1782-5.

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