Oncogenesis in HIV-infection.
Albini A, Aluigi M, Benelli R, Biberfeld P, Blasig C, Calabro M, Calvo F, Chieco-Bianchi L, Corbellino M, Del Mistro A, Ekman M, Favero A, Hofschneider PH, Kaaya E, Lebbe C, Morel P, Neipel F, Noonan D, Parravicini C, Repetto L, Schalling M, Stürzl M, Tschachler E (1996)
Publication Status: Published
Publication Type: Journal article
Publication year: 1996
Journal
Book Volume: 9
Pages Range: 5-8
Journal Issue: 1
DOI: 10.3892/ijo.9.1.5
Abstract
The presence of human Kaposi's sarcoma associated herpesvirus-like sequences (KSHV) was examined in different epidemiological variants of Kaposi's sarcoma (KS) and in KS-derived cell cultures by polymerase chain reaction (PCR). KSHV DNA was present in all tumor biopsies of AIDS-associated KS (59 biopsies), endemic KS (26 biopsies; 21 African endemic KS, 5 Greek endemic KS), sporadic/classical KS (28 biopsies) and post-transplant/iatrogenic KS (6 of 7 biopsies). On the contrary, these sequences were only detected rarely in non-involved skin of KS patients (3 positive specimens of 12), in the peripheral blood mononuclear cells of HIV-infected patients (3 positive specimens of 54) and in lymphoma-biopsies (3 positive specimens of 47). Cell cultures derived from KS skin lesions were positive for KSHV DNA only in the first two passages. However, two longer-term positive cultures from a biopsy of a patient affected with sporadic KS and a biopsy of a patient affected with epidemic KS was identified. A strong association of KSHV with KS tissue was observed in all the different epidemiological variants of KS. Long-term positive KS-derived cell cultures will be an important tool to study the herpesvirus-like agent and to investigate its functional role in the initiation and progression of KS.
Authors with CRIS profile
Frank Neipel
Institute of Clinical and Molecular Virology
Michael Stürzl
Professur für Molekulare und Experimentelle Chirurgie
Involved external institutions
Ospedale Policlinico San Martino
Italy (IT)
Medizinische Universität Wien
Austria (AT)
Karolinska Institute
Sweden (SE)
Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal
France (FR)
Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry
Germany (DE)
Italy (IT)
Medizinische Universität Wien
Austria (AT)
Karolinska Institute
Sweden (SE)
Hôpitaux Universitaires Saint-Louis, Lariboisière, Fernand-Widal
France (FR)
Max-Planck-Institut für Biochemie / Max Planck Institute of Biochemistry
Germany (DE)
How to cite
APA:
Albini, A., Aluigi, M., Benelli, R., Biberfeld, P., Blasig, C., Calabro, M.,... Tschachler, E. (1996). Oncogenesis in HIV-infection. International Journal of Oncology, 9(1), 5-8. https://doi.org/10.3892/ijo.9.1.5
MLA:
Albini, Adriana, et al. "Oncogenesis in HIV-infection." International Journal of Oncology 9.1 (1996): 5-8.
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