The contribution of systems biology and reverse genetics to the understanding of Kaposi's sarcoma-associated herpesvirus pathogenesis in endothelial cells.
Stürzl M, Konrad A, Alkharsah KR, Jochmann R, Thurau M, Marquardt G, Schulz TF (2009)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2009
Journal
Book Volume: 102
Pages Range: 1117-34
Journal Issue: 6
DOI: 10.1160/TH09-07-0472
Abstract
Kaposi's sarcoma-associated herpesvirus (KSHV)/human herpesvirus-8 is the causative agent of the endothelial cell-derived tumour Kaposi's sarcoma. Herpesviruses possess large complex genomes which provide many options to regulate cellular physiology during the viral life cycle and in the course of tumourigenicity. Novel techniques of systems biology and reverse genetics are increasingly applied to dissect the complex interaction of KSHV with endothelial cells. This review will outline novel results and pitfalls of these technologies in the elucidation of KSHV pathogenicity.
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Germany (DE)How to cite
APA:
Stürzl, M., Konrad, A., Alkharsah, K.R., Jochmann, R., Thurau, M., Marquardt, G., & Schulz, T.F. (2009). The contribution of systems biology and reverse genetics to the understanding of Kaposi's sarcoma-associated herpesvirus pathogenesis in endothelial cells. Thrombosis and Haemostasis, 102(6), 1117-34. https://doi.org/10.1160/TH09-07-0472
MLA:
Stürzl, Michael, et al. "The contribution of systems biology and reverse genetics to the understanding of Kaposi's sarcoma-associated herpesvirus pathogenesis in endothelial cells." Thrombosis and Haemostasis 102.6 (2009): 1117-34.
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