Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effusion lymphoma.
Ensoli B, Stürzl M, Monini P (2000)
Publication Status: Published
Publication Type: Journal article, Review article
Publication year: 2000
Journal
Book Volume: 10
Pages Range: 367-81
Journal Issue: 5
Abstract
Kaposi's sarcoma (KS) is an angioproliferative disease particularly frequent and aggressive in patients with AIDS but occurring also in post-transplant patients or in immunocompetent individuals of certain geographic areas. At least in its early stages, KS behaves as a reactive hyperplastic process mediated by inflammatory cytokines and angiogenic factors triggered or exacerbated by human herpesvirus-8 (HHV-8) infection. The HIV Tat protein appears to be responsible for the highly aggressive nature of AIDS-KS. Over time, however, KS may evolve into a true sarcoma in association with the expression of oncogenes and/or HHV-8 latency genes endowed with growth and anti-apoptotic properties. HHV-8 infection is also associated with primary effusion lymphoma (PEL), a rare tumor that similarly develops more frequently in the setting of HIV infection. HHV-8 latency genes are likely to contribute to the neoplastic phenotype of PEL cells, whose growth in vivo may require cytokines and factors from the host, or encoded by the virus.
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Italy (IT)How to cite
APA:
Ensoli, B., Stürzl, M., & Monini, P. (2000). Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effusion lymphoma. Seminars in Cancer Biology, 10(5), 367-81. https://doi.org/10.1006/scbi.2000.0329
MLA:
Ensoli, Barbara, Michael Stürzl, and Paolo Monini. "Cytokine-mediated growth promotion of Kaposi's sarcoma and primary effusion lymphoma." Seminars in Cancer Biology 10.5 (2000): 367-81.
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