Update Breast Cancer 2020 Part 2 - Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics

Lüftner D, Schneeweiss A, Hartkopf AD, Müller V, Wöckel A, Janni W, Ettl J, Belleville E, Schütz F, Thill M, Huober J, Fasching P, Kolberg HC, Pöschke P, Welslau M, Overkamp F, Tesch H, Fehm TN, Lux MP (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Geburtshilfe und Frauenheilkunde Georg Thieme Verlag

Book Volume: 80

Pages Range: 391-398

Journal Issue: 4

DOI: 10.1055/a-1111-8775

Abstract

For patients with locally advanced or metastatic breast cancer, new and effective therapies such as CDK4/6 inhibitors, PARP inhibitors and a PD-L1 inhibitor have been introduced in recent years. This review presents an update on the available studies with their data. In addition, two innovative anti-HER2 therapies are presented (trastuzumab-deruxtecan and tucatinib) for which the results from new studies have been reported. Molecular tests offer the possibility of defining patient populations or also monitoring courses of therapy. This can help identify patients with specific characteristics in order to provide them with individually targeted therapy within the framework of studies. In a large study, the benefit of such a biomarker study was able to be described for the first time.

Authors with CRIS profile

Peter Fasching Professur für Translationale Frauenheilkunde und Geburtshilfe Patrik Pöschke Department of Obstetrics and Gynaecology

Involved external institutions

St. Vincenz-Krankenhaus DE Germany (DE) Ruprecht-Karls-Universität Heidelberg DE Germany (DE) Charité - Universitätsmedizin Berlin DE Germany (DE) Universitätsklinikum Ulm DE Germany (DE) Klinikum Aschaffenburg DE Germany (DE) Agaplesion Markus Krankenhaus DE Germany (DE) Klinikum rechts der Isar DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) Universitätsklinikum Hamburg-Eppendorf (UKE) DE Germany (DE) Marienhospital Bottrop DE Germany (DE) Universitätsklinikum Würzburg DE Germany (DE) OncoConsult DE Germany (DE) ClinSol GmbH & Co.KG DE Germany (DE) Eberhard Karls Universität Tübingen DE Germany (DE) Universitätsklinikum Heidelberg DE Germany (DE)

How to cite

APA:

Lüftner, D., Schneeweiss, A., Hartkopf, A.D., Müller, V., Wöckel, A., Janni, W.,... Lux, M.P. (2020). Update Breast Cancer 2020 Part 2 - Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics. Geburtshilfe und Frauenheilkunde, 80(4), 391-398. https://doi.org/10.1055/a-1111-8775

MLA:

Lüftner, Diana, et al. "Update Breast Cancer 2020 Part 2 - Advanced Breast Cancer: New Treatments and Implementation of Therapies with Companion Diagnostics." Geburtshilfe und Frauenheilkunde 80.4 (2020): 391-398.

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