Autologous hematopoietic stem cell transplantation for systemic sclerosis: Position statement of the stem cell therapy working party of the German Society of Rheumatology Autologe hämatopoetische Stammzelltransplantation bei systemischer Sklerose: Positionspapier des Arbeitskreises Stammzelltherapie der Deutschen Gesellschaft für Rheumatologie
Alexander T, Henes J, Distler J, Schmalzing M, Blank N, Kötter I, Hiepe F (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
DOI: 10.1007/s00393-020-00789-0
Abstract
There have been three randomized controlled trials on autologous hematopoietic stem cell transplantation (AHSCT) in systemic sclerosis (SSc) that demonstrated significant superiority with respect to survival, improvement of cutaneous fibrosis, lung function and quality of life compared to standard treatment; however, these advantages must be carefully weighed against the transplantation-related risks. For this reason, an expert group from the stem cell therapy working party of the German Society for Rheumatology (DGRh) has now developed recommendations for the use of AHSCT in SSc. Based on the high-quality evidence, AHSCT is considered as the standard option for the treatment of selected SSc patients. Potential candidates for AHSCT are those with early, rapidly progressive, diffuse cutaneous SSc with visceral manifestations who have not yet developed severe damage to internal organs. A close cooperation between rheumatologists and transplantation centers is crucial for optimizing patient selection and treatment outcomes.
Authors with CRIS profile
Involved external institutions
Charité - Universitätsmedizin Berlin
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
Germany (DE)
Universitätsklinikum Tübingen
Germany (DE)
Universitätsklinikum Würzburg
Germany (DE)
Universitätsklinikum Heidelberg
Germany (DE)
Universitätsklinikum Hamburg-Eppendorf (UKE)
Germany (DE)
How to cite
APA:
Alexander, T., Henes, J., Distler, J., Schmalzing, M., Blank, N., Kötter, I., & Hiepe, F. (2020). Autologous hematopoietic stem cell transplantation for systemic sclerosis: Position statement of the stem cell therapy working party of the German Society of Rheumatology Autologe hämatopoetische Stammzelltransplantation bei systemischer Sklerose: Positionspapier des Arbeitskreises Stammzelltherapie der Deutschen Gesellschaft für Rheumatologie. Zeitschrift für Rheumatologie. https://doi.org/10.1007/s00393-020-00789-0
MLA:
Alexander, T., et al. "Autologous hematopoietic stem cell transplantation for systemic sclerosis: Position statement of the stem cell therapy working party of the German Society of Rheumatology Autologe hämatopoetische Stammzelltransplantation bei systemischer Sklerose: Positionspapier des Arbeitskreises Stammzelltherapie der Deutschen Gesellschaft für Rheumatologie." Zeitschrift für Rheumatologie (2020).
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