Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation

Herrmann L, Filip A, Lapuente D, Tenbusch M, Niehaus K, Rudolph V, Farr M (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Biochemical and Biophysical Research Communications Elsevier

DOI: 10.1016/j.bbrc.2020.03.082

Abstract

The Coxsackie- and adenovirus receptor (CAR) mediates homophilic cell-cell contacts and susceptibility to both human pathogenic viruses through its membrane-distal immunoglobulin domain. In the present study, we screened five missense variants of the human CAR gene for their influence on adenovector or Coxsackievirus entry into Chinese hamster ovary cells. The CAR variants facilitated virus internalisation to a similar extent as wild type CAR. This underlines CAR's presumed invariance and essential physiological role in embryogenesis.

Authors with CRIS profile

Matthias Tenbusch Professur für Genbasierte Immunisierungsverfahren

Involved external institutions

Universität Bielefeld DE Germany (DE) Herz- und Diabeteszentrum Nordrhein-Westfalen DE Germany (DE)

How to cite

APA:

Herrmann, L., Filip, A., Lapuente, D., Tenbusch, M., Niehaus, K., Rudolph, V., & Farr, M. (2020). Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation. Biochemical and Biophysical Research Communications. https://doi.org/10.1016/j.bbrc.2020.03.082

MLA:

Herrmann, Leonie, et al. "Naturally occurring variants in the transmembrane and cytoplasmic domains of the human Coxsackie- and adenovirus receptor have no impact on virus internalisation." Biochemical and Biophysical Research Communications (2020).

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