Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review
Maretzke F, Bechthold A, Egert S, Ernst JB, Melo van Lent D, Pilz S, Reichrath J, Stangl GI, Stehle P, Volkert D, Wagner M, Waizenegger J, Zittermann A, Linseisen J (2020)
Publication Type: Journal article, Review article
Publication year: 2020
Journal
Book Volume: 12
Journal Issue: 4
DOI: 10.3390/nu12040969
Abstract
Evidence is accumulating that vitamin D may have beneficial effects on respiratory tract, autoimmune, neuro-degenerative, and mental diseases. The present umbrella review of systematic reviews (SRs) of cohort studies and randomised controlled trials (RCTs), plus single Mendelian randomisation studies aims to update current knowledge on the potential role of vitamin D in preventing and treating these extraskeletal diseases. Altogether, 73 SRs were identified. Observational data on primary prevention suggest an inverse association between vitamin D status and the risk of acute respiratory tract infections (ARI), dementia and cognitive decline, and depression, whereas studies regarding asthma, multiple sclerosis (MS), and type 1 diabetes mellitus (T1DM) are scarce. SRs of RCTs support observational data only for the risk of ARI. No respective RCTs are available for the prevention of chronic obstructive pulmonary disease (COPD), MS, and T1DM. SRs of RCTs indicate beneficial therapeutic effects in vitamin D-deficient patients with asthma and COPD, while effects on major depression and T1DM need to be further elucidated. Mendelian randomisation studies do not consistently support the results of SRs. Since several limitations of the included SRs and existing RCTs do not permit definitive conclusions regarding vitamin D and the selected diseases, further high-quality RCTs are warranted.
Authors with CRIS profile
Involved external institutions
Deutsche Gesellschaft für Ernährung e.V.
Germany (DE)
Medizinische Universität Graz
Austria (AT)
Universität Hohenheim
Germany (DE)
UT Health San Antonio
United States (USA) (US)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
Martin-Luther-Universität Halle-Wittenberg (MLU)
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Herz- und Diabeteszentrum Nordrhein-Westfalen
Germany (DE)
Germany (DE)
Medizinische Universität Graz
Austria (AT)
Universität Hohenheim
Germany (DE)
UT Health San Antonio
United States (USA) (US)
Universitätsklinikum des Saarlandes (UKS)
Germany (DE)
Martin-Luther-Universität Halle-Wittenberg (MLU)
Germany (DE)
Rheinische Friedrich-Wilhelms-Universität Bonn
Germany (DE)
Universitätsklinikum Bonn
Germany (DE)
Herz- und Diabeteszentrum Nordrhein-Westfalen
Germany (DE)
How to cite
APA:
Maretzke, F., Bechthold, A., Egert, S., Ernst, J.B., Melo van Lent, D., Pilz, S.,... Linseisen, J. (2020). Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review. Nutrients, 12(4). https://doi.org/10.3390/nu12040969
MLA:
Maretzke, Friederike, et al. "Role of Vitamin D in Preventing and Treating Selected Extraskeletal Diseases-An Umbrella Review." Nutrients 12.4 (2020).
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