Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography

Jung S, Bosch A, Ott C, Kannenkeril D, Dienemann T, Harazny JM, Michelson G, Schmieder R (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Scientific Reports Nature Publishing Group: Open Access Journals - Option B

Book Volume: 10

Article Number: 5255

Journal Issue: 1

DOI: 10.1038/s41598-020-61308-4

Abstract

Spectral-domain optical coherence tomography (SD-OCT) represents a reliable tool for retinal layer volume and thickness measurement. The aim of this study was to evaluate retinal changes indicating neurodegenerative processes in patients with end-stage renal disease (ESRD) compared to healthy controls. This was a cross-sectional, single-center study comprising 32 ESRD patients and 38 controls. Sectoral retinal nerve fiber layer (RNFL) thickness and retinal layer volumes were obtained by SD-OCT. Age- and gender-adjusted retinal layer volumes such as total retinal volume (p = 0.037), ganglion cell layer volume (GCL, p = 0.003), ganglion cell layer – inner plexiform layer volume (GCL-IPL, p = 0.005) and inner retinal layer volume (IRL, p = 0.042) of the right eye were lower in ESRD patients. Inner plexiform layer volume of both eyes (IPL, right eye: p = 0.017; left eye: 0.044) was reduced, as was RNFL thickness in the temporal superior sector (right eye: p = 0.016). A subgroup analysis excluding patients with diabetes revealed that GCL (p = 0.014) and GCL-IPL volume of the right eye (p = 0.024) and temporal superior sector of the RNFL scan (p = 0.021) in ESRD patients were still significantly thinner. We observed a decrease in several retinal layer volumes and temporal RNFL thickness indicative of retinal neurodegenerative processes in patients with ESRD.

Authors with CRIS profile

Agnes Bosch Department of Medicine 4 – Nephrology and Hypertension Christian Ott Department of Medicine 4 – Nephrology and Hypertension Georg Michelson Department of Ophthalmology Roland Schmieder Professur für Innere Medizin (Nephrologie)

How to cite

APA:

Jung, S., Bosch, A., Ott, C., Kannenkeril, D., Dienemann, T., Harazny, J.M.,... Schmieder, R. (2020). Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography. Scientific Reports, 10(1). https://doi.org/10.1038/s41598-020-61308-4

MLA:

Jung, Susanne, et al. "Retinal neurodegeneration in patients with end-stage renal disease assessed by spectral-domain optical coherence tomography." Scientific Reports 10.1 (2020).

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