Computational Approaches in microRNA Biology

Schmitz U, Gupta SK, Vera J, Wolkenhauer O (2019)

Publication Type: Book chapter / Article in edited volumes

Publication year: 2019

Edited Volumes: Encyclopedia of Biomedical Engineering, Vol. 3

Series: Reference Module in Biomedical Sciences

Pages Range: 317-330

DOI: 10.1016/B978-0-12-801238-3.99997-5

Abstract

MicroRNAs (miRNAs) are small noncoding RNAs that regulate gene expression at the posttranscriptional level by binding to mRNA targets and inducing translational repression or target degradation via the RNA-induced silencing complex. Since miRNAs were first identified, computational approaches have played an important role for understanding their biosynthesis, modes of target regulation, and interplay with other mechanisms of gene regulation. In this essay we discuss computational methodologies used in miRNA biology research. More specifically, we introduce concepts for the prediction of miRNAs and their target genes: miRNA structure prediction and miRNA expression profiling approaches, coupled with the functional characterization of miRNAs. We then review approaches used for modeling miRNA-mediated gene regulatory networks.

Authors with CRIS profile

Julio Vera González Professur für Tumorimmunologie (Schwerpunkt Systembiologie)

Involved external institutions

Universität Rostock DE Germany (DE) Centenary Institute AU Australia (AU)

How to cite

APA:

Schmitz, U., Gupta, S.K., Vera, J., & Wolkenhauer, O. (2019). Computational Approaches in microRNA Biology. In Roger Narayan (Eds.), Encyclopedia of Biomedical Engineering, Vol. 3. (pp. 317-330).

MLA:

Schmitz, Ulf, et al. "Computational Approaches in microRNA Biology." Encyclopedia of Biomedical Engineering, Vol. 3. Ed. Roger Narayan, 2019. 317-330.

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