Mitochondria in Ischemic Stroke: New Insight and Implications
Liu F, Lu J, Manaenko A, Tang J, Hu Q (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 9
Pages Range: 924-937
Journal Issue: 5
Abstract
Stroke is the leading cause of death and adult disability worldwide. Mitochondrial dysfunction has been regarded as one of the hallmarks of ischemia/reperfusion (I/R) induced neuronal death. Maintaining the function of mitochondria is crucial in promoting neuron survival and neurological improvement. In this article, we review current progress regarding the roles of mitochondria in the pathological process of cerebral I/R injury. In particular, we emphasize on the most critical mechanisms responsible for mitochondrial quality control, as well as the recent findings on mitochondrial transfer in acute stroke. We highlight the potential of mitochondria as therapeutic targets for stroke treatment and provide valuable insights for clinical strategies.
Involved external institutions
China (CN)How to cite
APA:
Liu, F., Lu, J., Manaenko, A., Tang, J., & Hu, Q. (2018). Mitochondria in Ischemic Stroke: New Insight and Implications. Aging and Disease, 9(5), 924-937. https://dx.doi.org/10.14336/AD.2017.1126
MLA:
Liu, Fan, et al. "Mitochondria in Ischemic Stroke: New Insight and Implications." Aging and Disease 9.5 (2018): 924-937.
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