Perception of Agrobacterium tumefaciens flagellin by FLS2XL confers resistance to crown gall disease

Fuerst U, Zeng Y, Albert M, Witte AK, Fliegmann J, Felix G (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Nature Plants Nature Publishing Group

Book Volume: 6

Pages Range: 22-27

Journal Issue: 1

DOI: 10.1038/s41477-019-0578-6

Abstract

Bacterial flagella are perceived by the innate immune systems of plants¹ and animals² alike, triggering resistance. Common to higher plants is the immunoreceptor FLAGELLIN-SENSING 2 (FLS2)³, which detects flagellin via its most conserved epitope, flg22. Agrobacterium tumefaciens, which causes crown gall disease in many crop plants, has a highly diverged flg22 epitope and evades immunodetection by plants so far studied. We asked whether, as a next step in this game of ‘hide and seek’, there are plant species that have evolved immunoreceptors with specificity for the camouflaged flg22^Atum of A. tumefaciens. In the wild grape species Vitis riparia, we discovered FLS2^XL, a previously unknown form of FLS2, that provides exquisite sensitivity to typical flg22 and to flg22^Atum. As exemplified by ectopic expression in tobacco, FLS2^XL can limit crown gall disease caused by A. tumefaciens.

Authors with CRIS profile

Markus Albert

Additional Organisation(s)

Lehrstuhl für Molekulare Pflanzenphysiologie

Involved external institutions

Eberhard Karls Universität Tübingen

Germany (DE) University of Chicago

United States (USA) (US) HTK Hygiene Technologie Kompetenzzentrum GmbH

Germany (DE)

How to cite

APA:

Fuerst, U., Zeng, Y., Albert, M., Witte, A.K., Fliegmann, J., & Felix, G. (2020). Perception of Agrobacterium tumefaciens flagellin by FLS2XL confers resistance to crown gall disease. Nature Plants, 6(1), 22-27. https://dx.doi.org/10.1038/s41477-019-0578-6

MLA:

Fuerst, Ursula, et al. "Perception of Agrobacterium tumefaciens flagellin by FLS2XL confers resistance to crown gall disease." Nature Plants 6.1 (2020): 22-27.

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