The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis
Hipp G, Vaillant M, Diederich NJ, Roomp K, Satagopam VP, Banda P, Sandt E, Mommaerts K, Schmitz SK, Longhino L, Schweicher A, Hanff AM, Nicolai B, Kolber P, Reiter D, Pavelka L, Binck S, Pauly C, Geffers L, Betsou F, Gantenbein M, Klucken J, Gasser T, Hu MT, Balling R, Kruger R (2018)
Publication Type: Journal article
Publication year: 2018
Journal
Book Volume: 10
Pages Range: 326
Abstract
While genetic advances have successfully defined part of the complexity in Parkinson's disease (PD), the clinical characterization of phenotypes remains challenging. Therapeutic trials and cohort studies typically include patients with earlier disease stages and exclude comorbidities, thus ignoring a substantial part of the real-world PD population. To account for these limitations, we implemented the Luxembourg PD study as a comprehensive clinical, molecular and device-based approach including patients with typical PD and atypical parkinsonism, irrespective of their disease stage, age, comorbidities, or linguistic background. To provide a large, longitudinally followed, and deeply phenotyped set of patients and controls for clinical and fundamental research on PD, we implemented an open-source digital platform that can be harmonized with international PD cohort studies. Our interests also reflect Luxembourg-specific areas of PD research, including vision, gait, and cognition. This effort is flanked by comprehensive biosampling efforts assuring high quality and sustained availability of body liquids and tissue biopsies. We provide evidence for the feasibility of such a cohort program with deep phenotyping and high quality biosampling on parkinsonism in an environment with structural specificities and alert the international research community to our willingness to collaborate with other centers. The combination of advanced clinical phenotyping approaches including device-based assessment will create a comprehensive assessment of the disease and its variants, its interaction with comorbidities and its progression. We envision the Luxembourg Parkinson's study as an important research platform for defining early diagnosis and progression markers that translate into stratified treatment approaches.
Authors with CRIS profile
Involved external institutions
Luxembourg Hospital Center / Centre Hospitalier de Luxembourg (CHL)
Luxembourg (LU)
University of Luxembourg
Luxembourg (LU)
Luxembourg Institute of Health (CRP-Santé)
Luxembourg (LU)
Integrated Biobank of Luxembourg: IBBL
Luxembourg (LU)
Hertie-Institut für klinische Hirnforschung
Germany (DE)
University of Oxford
United Kingdom (GB)
Luxembourg (LU)
University of Luxembourg
Luxembourg (LU)
Luxembourg Institute of Health (CRP-Santé)
Luxembourg (LU)
Integrated Biobank of Luxembourg: IBBL
Luxembourg (LU)
Hertie-Institut für klinische Hirnforschung
Germany (DE)
University of Oxford
United Kingdom (GB)
How to cite
APA:
Hipp, G., Vaillant, M., Diederich, N.J., Roomp, K., Satagopam, V.P., Banda, P.,... Kruger, R. (2018). The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis. Frontiers in Aging Neuroscience, 10, 326. https://doi.org/10.3389/fnagi.2018.00326
MLA:
Hipp, Geraldine, et al. "The Luxembourg Parkinson's Study: A Comprehensive Approach for Stratification and Early Diagnosis." Frontiers in Aging Neuroscience 10 (2018): 326.
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