Copeptin levels in patients with treatment resistant hypertension before and six months after renal denervation

Bosch A, Schmid A, Ott C, Kannenkeril D, Karg MV, Ditting T, Veelken R, Uder M, Schmieder R (2019)

Publication Type: Journal article

Publication year: 2019

Journal

American Journal of Hypertension Oxford University Press

Abstract

BACKGROUND: Copeptin, the C-terminal peptide of pro-vasopressin, is released from the neurohypophysis and reflects the activity of the hormone arginine vasopressin in patients with hypertension. Elevated copeptin levels are associated with increased cardiovascular and all-cause mortality. The aim of this study is to compare copeptin levels in patients with treatment resistant hypertension (TRH) before and 6 months after renal denervation (RDN). METHODS: Copeptin was measured in 34 patients with TRH and 30 patients with primary hypertension stage 1 or 2 (HT). In addition, copeptin levels were measured in patients with TRH at 6 month follow-up visit after RDN. RDN was performed by an experienced interventionalist applying at least four ablations longitudinally and rotationally within the lengths of each renal artery to cover a full four quadrant ablation. RESULTS: In patients with TRH 24h ambulatory blood pressure (BP) decreased from 154±15/ 87±12 mmHg to 146±13/ 83±7.9 mmHg after RDN (systolic: p=0.001, diastolic: p=0.034). There was no significant change in copeptin levels in these 34 patients with TRH before versus six months after RDN (median 8.4 [interquartile range 3.6-14] vs 8.5 [4.5-13] pmol/l, p=0.334). Patients with TRH had higher copeptin levels (p=0.024) than patients with HT (24h ambulatory BP: 142±11/ 91±8.3 mmHg, copeptin: 4.2 [2.8-6.3] pmol/l). CONCLUSION: Patients with TRH showed 2 fold higher copeptin levels than patients with HT. RDN did not lead to any change of copeptin levels in patients with TRH 6 months after procedure despite significant fall in BP.

Authors with CRIS profile

Agnes Bosch Department of Medicine 4 – Nephrology and Hypertension Axel Schmid Institute of Radiology Christian Ott Department of Medicine 4 – Nephrology and Hypertension Roland Veelken Medizinische Fakultät Michael Uder Lehrstuhl für Diagnostische Radiologie Roland Schmieder Professur für Innere Medizin (Nephrologie)

How to cite

APA:

Bosch, A., Schmid, A., Ott, C., Kannenkeril, D., Karg, M.V., Ditting, T.,... Schmieder, R. (2019). Copeptin levels in patients with treatment resistant hypertension before and six months after renal denervation. American Journal of Hypertension. https://doi.org/10.1093/ajh/hpz155

MLA:

Bosch, Agnes, et al. "Copeptin levels in patients with treatment resistant hypertension before and six months after renal denervation." American Journal of Hypertension (2019).

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