What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori.

Backert S, Naumann M (2010)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2010

Journal

Trends in Microbiology Elsevier

Book Volume: 18

Pages Range: 479-86

Journal Issue: 11

DOI: 10.1016/j.tim.2010.08.003

Abstract

Infection of gastric epithelial cells with Helicobacter pylori induces strong proinflammatory responses by activating nuclear transcription factors NF-κB and AP-1. Several reports indicate that multiple bacterial factors and cellular molecules are involved in this signaling. Injected peptidoglycan, CagA or OipA and urease, and at least 16 different signaling cascades have been implicated in H. pylori-induced proinflammatory signaling. Many of these reports are contradictory, thus generating a highly puzzling scenario. Here we discuss the pros and cons of the multiple signaling activities in the induction of proinflammatory responses and associated problems, and give suggestions for finding ways out of this dilemma.

Authors with CRIS profile

Steffen Backert

Involved external institutions

Otto-von-Guericke-Universität Magdeburg DE Germany (DE) University College Dublin (UCD) IE Ireland (IE)

How to cite

APA:

Backert, S., & Naumann, M. (2010). What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori. Trends in Microbiology, 18(11), 479-86. https://doi.org/10.1016/j.tim.2010.08.003

MLA:

Backert, Steffen, and Michael Naumann. "What a disorder: proinflammatory signaling pathways induced by Helicobacter pylori." Trends in Microbiology 18.11 (2010): 479-86.

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