Emerging roles of Abl family tyrosine kinases in microbial pathogenesis.

Backert S, Feller SM, Wessler S (2008)

Publication Status: Published

Publication Type: Journal article, Review article

Publication year: 2008

Journal

Trends in Biochemical Sciences Elsevier

Book Volume: 33

Pages Range: 80-90

Journal Issue: 2

DOI: 10.1016/j.tibs.2007.10.006

Abstract

Abl family kinases are central regulators of multiple cellular processes controlling actin dynamics, proliferation and differentiation. Recent studies indicate that different pathogens highjack Abl kinase signalling to reorganize the host actin cytoskeleton and promote the tyrosine phosphorylation of four known bacterial and viral effector proteins. Abl signalling is implicated in such diverse processes as microbial invasion, viral release from host cells, actin-based motility, actin-rich pedestal formation and cell scattering. Thus, Abl kinases are emerging as crucial regulators of multiple pathological signalling cascades during infection. Therapeutic intervention against Abl kinase activity might be an effective and novel strategy to combat serious microbial diseases.

Authors with CRIS profile

Steffen Backert

Involved external institutions

Paul Ehrlich Institute / Paul-Ehrlich-Institut – Bundesinstitut für Impfstoffe und biomedizinische Arzneimittel (PEI) DE Germany (DE) University of Oxford GB United Kingdom (GB) Otto-von-Guericke-Universität Magdeburg DE Germany (DE)

How to cite

APA:

Backert, S., Feller, S.M., & Wessler, S. (2008). Emerging roles of Abl family tyrosine kinases in microbial pathogenesis. Trends in Biochemical Sciences, 33(2), 80-90. https://doi.org/10.1016/j.tibs.2007.10.006

MLA:

Backert, Steffen, Stephan M. Feller, and Silja Wessler. "Emerging roles of Abl family tyrosine kinases in microbial pathogenesis." Trends in Biochemical Sciences 33.2 (2008): 80-90.

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