White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation

Teunissen CE, Otto M, Engelborghs S, Herukka SK, Lehmann S, Lewczuk P, Lleo A, Perret-Liaudet A, Tumani H, Turner MR, Verbeek MM, Wiltfang J, Zetterberg H, Parnetti L, Blennow K (2018)

Publication Type: Journal article

Publication year: 2018

Journal

Alzheimer's Research and Therapy BioMed Central

Book Volume: 10

Pages Range: 30

Journal Issue: 1

DOI: 10.1186/s13195-018-0359-x

Abstract

Body fluid biomarkers have great potential for different clinical purposes, including diagnosis, prognosis, patient stratification and treatment effect monitoring. This is exemplified by current use of several excellent biomarkers, such as the Alzheimer's disease cerebrospinal fluid (CSF) biomarkers, anti-neuromyelitis optica antibodies and blood neurofilament light. We still, however, have a strong need for additional biomarkers and several gaps in their development and implementation should be filled. Examples of such gaps are i) limited knowledge of the causes of neurological diseases, and thus hypotheses about the best biomarkers to detect subclinical stages of these diseases; ii) the limited success translating discoveries obtained by e.g. initial mass spectrometry proteomic low-throughput studies into immunoassays for widespread clinical implementation; iii) lack of interaction among all stakeholders to optimise and adapt study designs throughout the biomarker development process to medical needs, which may change during the long period needed for biomarker development.The Society for CSF Analysis and Clinical Neurochemistry (established in 2015) has been founded as a concerted follow-up of large standardisation projects, including BIOMARKAPD and SOPHIA, and the BioMS-consortium.The main aims of the CSF society are to exchange high level international scientific experience, to facilitate the incorporation of CSF diagnostics into clinical practice and to give advice on inclusion of CSF analysis into clinical guidelines. The society has a broad scope, as its vision is that the gaps in development and implementation of biomarkers are shared among almost all neurological diseases and thus they can benefit from the activities of the society.

Authors with CRIS profile

Piotr Lewczuk Department of Psychiatry and Psychotherapy

Involved external institutions

Vrije Universiteit Amsterdam (VU) / University Amsterdam NL Netherlands (NL) Autonomous University of Barcelona (UAB) / Universitat Autònoma de Barcelona ES Spain (ES) Sahlgrenska University Hospital / Sahlgrenska Universitetssjukhuset SE Sweden (SE) Radboud University Nijmegen NL Netherlands (NL) Università degli Studi di Perugia IT Italy (IT) Georg-August-Universität Göttingen DE Germany (DE) University of Oxford GB United Kingdom (GB) Universitätsklinikum Ulm DE Germany (DE) University of Montpellier / Université Montpellier FR France (FR) University of Antwerp / Universiteit Antwerpen BE Belgium (BE) University of Eastern Finland FI Finland (FI) Universität Ulm DE Germany (DE) Hospices Civils de Lyon (CHU) FR France (FR)

How to cite

APA:

Teunissen, C.E., Otto, M., Engelborghs, S., Herukka, S.-K., Lehmann, S., Lewczuk, P.,... Blennow, K. (2018). White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation. Alzheimer's Research and Therapy, 10(1), 30. https://doi.org/10.1186/s13195-018-0359-x

MLA:

Teunissen, Charlotte E., et al. "White paper by the Society for CSF Analysis and Clinical Neurochemistry: Overcoming barriers in biomarker development and clinical translation." Alzheimer's Research and Therapy 10.1 (2018): 30.

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