Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer's Disease

Mroczko B, Groblewska M, Litman-Zawadzka A, Kornhuber J, Lewczuk P (2018)

Publication Type: Journal article

Publication year: 2018

Journal

International Journal of Molecular Sciences MDPI

Book Volume: 19

Journal Issue: 7

DOI: 10.3390/ijms19071884

Abstract

It is estimated that Alzheimer’s disease (AD) affects tens of millions of people, comprising not only suffering patients, but also their relatives and caregivers. AD is one of age-related neurodegenerative diseases (NDs) characterized by progressive synaptic damage and neuronal loss, which result in gradual cognitive impairment leading to dementia. The cause of AD remains still unresolved, despite being studied for more than a century. The hallmark pathological features of this disease are senile plaques within patients’ brain composed of amyloid beta (Aβ) and neurofibrillary tangles (NFTs) of Tau protein. However, the roles of Aβ and Tau in AD pathology are being questioned and other causes of AD are postulated. One of the most interesting theories proposed is the causative role of amyloid β oligomers (AβOs) aggregation in the pathogenesis of AD. Moreover, binding of AβOs to cell membranes is probably mediated by certain proteins on the neuronal cell surface acting as AβO receptors. The aim of our paper is to describe alternative hypotheses of AD etiology, including genetic alterations and the role of misfolded proteins, especially Aβ oligomers, in Alzheimer’s disease. Furthermore, in this review we present various putative cellular AβO receptors related to toxic activity of oligomers.

Authors with CRIS profile

Johannes Kornhuber Lehrstuhl für Psychiatrie und Psychotherapie

Involved external institutions

University of Białystok PL Poland (PL) Medical University of Bialystok Clinical Hospital / Uniwersytecki Szpital Kliniczny w Białymstoku PL Poland (PL)

How to cite

APA:

Mroczko, B., Groblewska, M., Litman-Zawadzka, A., Kornhuber, J., & Lewczuk, P. (2018). Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer's Disease. International Journal of Molecular Sciences, 19(7). https://doi.org/10.3390/ijms19071884

MLA:

Mroczko, Barbara, et al. "Cellular Receptors of Amyloid β Oligomers (AβOs) in Alzheimer's Disease." International Journal of Molecular Sciences 19.7 (2018).

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