Commercially Available Gene Expression Assays as Predictive Tools for Adjuvant Radiotherapy? A Critical Review

Krug D, Baumann R, Budach W, Duma MN, Dunst J, Feyer P, Fietkau R, Haase W, Harms W, Hehr T, Piroth MD, Sedlmayer F, Souchon R, Wenz F, Sauer R (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Breast Care Karger

DOI: 10.1159/000505656

Abstract

Background: Gene expression assays are increasingly used for decision-making regarding adjuvant chemotherapy in patients with hormone receptor-positive, HER2-negative breast cancer. There are some clinical situations in which there is also a need for better prognostic and predictive markers to better estimate the amount of benefit from adjuvant radiotherapy. The rising availability of gene expression analyses prompts the question whether their results can also be used to guide clinical decisions regarding adjuvant radiation. Summary: Multiple studies suggest a correlation between results from gene expression assays and locoregional recurrence rates. Only few publications addressed the predictive value of results from gene expression analysis for the role of adjuvant radiotherapy in different settings. Key Messages: To date, the available evidence on the possible predictive value of gene expression assays for radiotherapy does not support their inclusion into the decision-making process for adjuvant radiation. This is due to methodological weaknesses and limitations regarding patient selection, the nonrandomized design of all studies in terms of radiotherapy use, and limited availability of tissue from prospective trials. Thus, utilization of the present knowledge for clinical indication of radiotherapy should be very cautious.

Authors with CRIS profile

Rainer Fietkau Lehrstuhl für Strahlentherapie

Involved external institutions

Universitätsklinikum Tübingen DE Germany (DE) Marienhospital Stuttgart DE Germany (DE) Paracelsus Medizinische Privatuniversität AT Austria (AT) St. Vincentius-Kliniken / ViDia Kliniken DE Germany (DE) Vivantes - Netzwerk für Gesundheit GmbH DE Germany (DE) Universitätsklinikum Düsseldorf DE Germany (DE) Universitätsklinikum Jena DE Germany (DE) Universitätsklinikum Schleswig-Holstein (UKSH) DE Germany (DE) Universität Witten/Herdecke DE Germany (DE) St. Claraspital AG CH Switzerland (CH) Universitätsklinikum Freiburg DE Germany (DE)

How to cite

APA:

Krug, D., Baumann, R., Budach, W., Duma, M.N., Dunst, J., Feyer, P.,... Sauer, R. (2020). Commercially Available Gene Expression Assays as Predictive Tools for Adjuvant Radiotherapy? A Critical Review. Breast Care. https://doi.org/10.1159/000505656

MLA:

Krug, David, et al. "Commercially Available Gene Expression Assays as Predictive Tools for Adjuvant Radiotherapy? A Critical Review." Breast Care (2020).

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