Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing's Disease - Analysis from the DPV Database

Warncke K, Kummer S, Kann PH, Bergis D, Bollow E, Hummel M, Zoicas F, Wernert S, Holl RW (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Experimental and Clinical Endocrinology and Diabetes Thieme Publishing

Book Volume: 128

Pages Range: 104-110

Journal Issue: 2

DOI: 10.1055/a-0600-9649

Abstract

BACKGROUND: Although diabetes is a common complication of acromegaly or Cushing´s disease, there are only few detailed studies with a focus on cardiovascular risk, metabolic control or diabetes therapy. Here, we provide a comprehensive characterization from the longitudinal DPV (Diabetes Patienten Verlaufsdokumentation) registry. METHODS: Patients from the registry≥18 years of age with diabetes and acromegaly or Cushing´s disease were compared to patients with type 1 diabetes or type 2 diabetes using the statistical software SAS 9.4. RESULTS: Patients with diabetes and acromegaly (n=52) or Cushing's disease (n=15) were significantly younger at diabetes onset (median age 50.1 and 45.0 vs. 59.0 years in type 2 diabetes; both p<0.05). Dyslipidemia was common in both diseases (71.0% and 88.9% vs. 71.8% in type 2 diabetes; n.s.), while hypertension was most frequent in acromegaly (56.8% vs. 20.9% in type 1 diabetes, p<0.00001). 36.5% of patients with acromegaly and 46.7% with Cushing´s disease receive insulin, compared to 50.4% with type 2 diabetes. Oral antidiabetic drugs were used in 36.5% of patients with acromegaly and 40% with Cushing´s disease, with a predominance of biguanides and dipeptidyl peptidase-4 inhibitors. HbA1c was well controlled in both groups (median 7.0% and 6.5%; vs. 7.2% in type 2 diabetes). CONCLUSION: Patients with acromegaly are at a high risk for cardiovascular disease, reflected by dyslipidemia and hypertension. A high proportion of patients with diabetes in acromegaly or Cushing´s disease receives insulin. Based on a multicenter register, a sufficient number of patients with rare forms of diabetes can be analyzed.

Involved external institutions

Universitätsklinikum Düsseldorf DE Germany (DE) Klinikum rechts der Isar DE Germany (DE) Universitätsklinikum Frankfurt am Main (KGU) DE Germany (DE) Vienna General Hospital / Allgemeines Krankenhaus der Stadt Wien (AKH) AT Austria (AT) Universität Ulm DE Germany (DE)

How to cite

APA:

Warncke, K., Kummer, S., Kann, P.H., Bergis, D., Bollow, E., Hummel, M.,... Holl, R.W. (2020). Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing's Disease - Analysis from the DPV Database. Experimental and Clinical Endocrinology and Diabetes, 128(2), 104-110. https://doi.org/10.1055/a-0600-9649

MLA:

Warncke, Katharina, et al. "Cardivascular Risk Profile in Patients with Diabetes and Acromegaly or Cushing's Disease - Analysis from the DPV Database." Experimental and Clinical Endocrinology and Diabetes 128.2 (2020): 104-110.

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