Bisphosphonate's Effect on Tongue Mucosa: An Experimental Electron Microscopy Study

Papamitsou T, Morsi-Yeroyannis A, Papanastasiou A, Bakalopoulos N, Dietrich EM, Karachrysafi S, Toskas A, Mareti E, Morsi-Yeroyanni A, Sioga A (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Medicina Kaunas University of Medicine

Book Volume: 56

Journal Issue: 2

DOI: 10.3390/medicina56020051

Abstract

BACKGROUND AND OBJECTIVES: Bisphosphonates (BPs) are selective inhibitors of osteoclasts, used for the treatment of bone disorders. The objective of this study is to investigate the possible effects of BPs on the tongue's mucosa. MATERIALS AND METHODS: Specimens of the tongue of 20 female 12-month old Wistar rats were taken. Ten were used as control group, while in the remaining alendronate (Fosamax, Merck) was administered per os from 13 weeks. Observation of the harvested samples was made by Transmission Electron Microscopy (TEM). RESULTS: In the experimental group, focal alterations were observed to various extent in all specimens. The basement membrane was intact. Furthermore, an increase at the intercellular space was observed, predominantly at the middle layer, and the desmosomes were disorganized. In the lamina propria focal edema was observed. CONCLUSIONS: Investigation on the effect of BPs on the tongue's mucosa through TEM hasn't been documented in the past. According to our results, BPs seem to cause mild mucosal lesions on the tongue.

Authors with CRIS profile

Eva-Maria Dietrich Department of Oral and Cranio-Maxillofacial Surgery

Involved external institutions

Aristotle University of Thessaloniki GR Greece (GR) George Papanikolaou General Hospital of Thessaloniki GR Greece (GR)

How to cite

APA:

Papamitsou, T., Morsi-Yeroyannis, A., Papanastasiou, A., Bakalopoulos, N., Dietrich, E.-M., Karachrysafi, S.,... Sioga, A. (2020). Bisphosphonate's Effect on Tongue Mucosa: An Experimental Electron Microscopy Study. Medicina, 56(2). https://dx.doi.org/10.3390/medicina56020051

MLA:

Papamitsou, Theodora, et al. "Bisphosphonate's Effect on Tongue Mucosa: An Experimental Electron Microscopy Study." Medicina 56.2 (2020).

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