Acute Kidney Injury and Renal Regional Oxygen Saturation During Pediatric Liver Transplantation
Sinner B, Banas M, Brunete-Lorenzo C, Zant R, Knoppke B, Scherer MN, Graf BM, Lunz D (2020)
Publication Type: Journal article, Original article
Publication year: 2020
Journal
Book Volume: 25
Pages Range: e919717-
DOI: 10.12659/AOT.919717
Abstract
BACKGROUND Kidney injury is a complication among children undergoing liver transplantation (pLTx). Cystatin C serum concentration seems to be superior to creatinine-based determination of kidney injury in adults and children. Near-infrared spectroscopy (NIRS) technology provides non-invasive and real-time measurement of renal tissue oxygenation. Here, we compared renal tissue oximetry (rSrO₂) with conventional diagnostic criteria cystatin C and creatinine concentration in children undergoing pLTx. MATERIAL AND METHODS rSrO₂ was measured intraoperatively in children undergoing pLTx over the left kidney, and was statistically compared with pre- and postoperative serum creatinine and cystatin C concentrations. RESULTS rSrO₂ was affected by hemoglobin concentration, bilirubin concentration, and FiO₂. Statistical analysis demonstrated that rSrO₂ was significantly reduced in children with preoperative pathologic increased cystatin C concentrations compared to children without (63.7±4.3 vs. 53.4±4.9, p<0.05). We did not detect a significant difference in rSrO₂ between children who developed postoperative renal impairment, either determined by increased postoperative cystatin C concentration, creatinine concentration, or the pRIFLE criteria. Intraoperative increase or decrease in rSrO₂ did not predict the development of postoperative kidney injury. CONCLUSIONS In children with liver failure undergoing pLTx, a preoperative decrease in rSrO₂ indicates compromised renal function. However, intraoperative rSrO₂ is not predictive of postoperative kidney injury.
Involved external institutions
Germany (DE)How to cite
APA:
Sinner, B., Banas, M., Brunete-Lorenzo, C., Zant, R., Knoppke, B., Scherer, M.N.,... Lunz, D. (2020). Acute Kidney Injury and Renal Regional Oxygen Saturation During Pediatric Liver Transplantation. Annals of Transplantation, 25, e919717-. https://dx.doi.org/10.12659/AOT.919717
MLA:
Sinner, Barbara, et al. "Acute Kidney Injury and Renal Regional Oxygen Saturation During Pediatric Liver Transplantation." Annals of Transplantation 25 (2020): e919717-.
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