Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment

Maniati E, Berlato C, Gopinathan G, Heath O, Kotantaki P, Lakhani A, McDermott J, Pegrum C, Delaine-Smith RM, Pearce OM, Hirani P, Joy JD, Szabova L, Perets R, Sansom OJ, Drapkin R, Bailey P, Balkwill FR (2020)

Publication Type: Journal article

Publication year: 2020

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 30

Pages Range: 525-540.e7

Journal Issue: 2

DOI: 10.1016/j.celrep.2019.12.034

Abstract

Maniati et al. show how orthotopic transplantable mouse ovarian cancers with appropriate genotypes develop microenvironments that replicate many features of human primary ovarian tumors and metastases. Molecular features of the mouse tumors combined with machine learning may allow the identification of patients who are most likely to respond to specific therapies.

Additional Organisation(s)

Professur für Chirurgische Forschung

Involved external institutions

Queen Mary University of London GB United Kingdom (GB) Cancer Research UK Beatson Institute GB United Kingdom (GB) Perelman School of Medicine University of Pennsylvania US United States (USA) (US) Technion - Israel Institute of Technology IL Israel (IL) The Frederick National Laboratory for Cancer Research US United States (USA) (US) University College London (UCL) GB United Kingdom (GB)

How to cite

APA:

Maniati, E., Berlato, C., Gopinathan, G., Heath, O., Kotantaki, P., Lakhani, A.,... Balkwill, F.R. (2020). Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment. Cell Reports, 30(2), 525-540.e7. https://dx.doi.org/10.1016/j.celrep.2019.12.034

MLA:

Maniati, Eleni, et al. "Mouse Ovarian Cancer Models Recapitulate the Human Tumor Microenvironment and Patient Response to Treatment." Cell Reports 30.2 (2020): 525-540.e7.

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