Upconversion Nanoparticle-Assisted Payload Delivery from TiO2 under Near-Infrared Light Irradiation for Bacterial Inactivation
Xu J, Liu N, Wu D, Gao Z, Song YY, Schmuki P (2020)
Publication Type: Journal article
Publication year: 2020
Journal
DOI: 10.1021/acsnano.9b05386
Abstract
The low penetration depth of UV light in mammalian tissue is the critical limitation for the use of TiO2-based photocatalysis in biomedical applications. In this work, we develop an effective near-infrared (NIR)-active photocatalytic platform that consists of a shell structure of upconversion nanocrystals decorated on a core of Au/dark-TiO2. The heart of this system is the strong photocatalytic activity in the visible region enabled by the gold surface-plasmon resonance on dark TiO2 (D-TiO2). Simulation and experiment demonstrate for an optimized Au/D-TiO2 combination a highly enhanced light absorption in the visible range. Using ampicillin sodium (AMP) as model drug, we exemplify the effective use of this principle by demonstrating a NIR light-triggered photocatalytic payload release. Importantly, the photocatalytically generated reactive oxygen species can effectively inactivate AMP-resistant bacteria strains, thus maintaining an antibacterial effect even after all drug is released. Overall, we anticipate that the here-introduced NIR-light-active photocatalytic cascade can considerably widen TiO2-based photocatalysis and its applications into the infrared range.
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APA:
Xu, J., Liu, N., Wu, D., Gao, Z., Song, Y.Y., & Schmuki, P. (2020). Upconversion Nanoparticle-Assisted Payload Delivery from TiO2 under Near-Infrared Light Irradiation for Bacterial Inactivation. ACS nano. https://doi.org/10.1021/acsnano.9b05386
MLA:
Xu, Jingwen, et al. "Upconversion Nanoparticle-Assisted Payload Delivery from TiO2 under Near-Infrared Light Irradiation for Bacterial Inactivation." ACS nano (2020).
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