Differential contribution of pyramidal cells and interneurons to activity-dependent gene transcription changes

Salar S, Guhathakurta D, Marx Hofmann L (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Journal of Neurophysiology American Physiological Society

Book Volume: 122

Pages Range: 2203-2205

Journal Issue: 6

DOI: 10.1152/jn.00089.2019

Abstract

The type of neuronal activity determines the outcome of gene expression. Hence, the characterization of underlying mechanisms in transcriptome alterations may serve as a biomarker and provide new intervention methods for the treatment of pathologic conditions. Parrish et al. (Parrish RR, Codadu NK, Racca C, Trevelyan AJ. J Neurophysiol 120: 2358-2367, 2018) show that the changes in interneuronal gene transcription are correlated with the type of the activated neuronal population and that the initiation route of Ras/ERK MAPK pathway determines the polarity of the gene expression.

Authors with CRIS profile

Seda Salar Department of Psychiatry and Psychotherapy

Additional Organisation(s)

Interdisziplinäres Zentrum für Klinische Forschung

Related research project(s)

IZKF-J74 (PS): The role of CtBP1 in hippocampal and cortical neuroplasticity Feb. 1, 2019 - July 31, 2021

How to cite

APA:

Salar, S., Guhathakurta, D., & Marx Hofmann, L. (2019). Differential contribution of pyramidal cells and interneurons to activity-dependent gene transcription changes. Journal of Neurophysiology, 122(6), 2203-2205. https://doi.org/10.1152/jn.00089.2019

MLA:

Salar, Seda, Debarpan Guhathakurta, and Lena Marx Hofmann. "Differential contribution of pyramidal cells and interneurons to activity-dependent gene transcription changes." Journal of Neurophysiology 122.6 (2019): 2203-2205.

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