In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species

Kiechle M, von Einem B, Höfs L, Voehringer P, Grozdanov V, Markx D, Parlato R, Wiesner D, Mayer B, Sakk O, Baumann B, Lukassen S, Liss B, Ekici AB, Ludolph AC, Walther P, Ferger B, McLean PJ, Falkenburger BH, Weishaupt JH, Danzer KM (2019)

Publication Type: Journal article

Publication year: 2019

Journal

Cell Reports Elsevier (Cell Press)

Book Volume: 29

Pages Range: 2862-2874.e9

Journal Issue: 9

DOI: 10.1016/j.celrep.2019.10.089

Abstract

Kiechle et al. present two transgenic mouse models that allow direct quantitative and spatial detection of α-synuclein (α-syn) oligomers in vivo. They demonstrate α-syn aggregation at the synapse, age-dependent accumulation of 8–16-mer α-syn oligomer species, and trans-cellular oligomer spreading from forebrain to hindbrain neurons.

Authors with CRIS profile

Sören Lukassen Professur für Humangenetik Arif Bülent Ekici Institute of Human Genetics

Involved external institutions

Universität Ulm DE Germany (DE) Universitätsklinikum Carl Gustav Carus Dresden DE Germany (DE) Boehringer Ingelheim Pharma GmbH & Co. KG DE Germany (DE) Mayo Clinic Hospital US United States (USA) (US)

How to cite

APA:

Kiechle, M., von Einem, B., Höfs, L., Voehringer, P., Grozdanov, V., Markx, D.,... Danzer, K.M. (2019). In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species. Cell Reports, 29(9), 2862-2874.e9. https://doi.org/10.1016/j.celrep.2019.10.089

MLA:

Kiechle, Martin, et al. "In Vivo Protein Complementation Demonstrates Presynaptic α-Synuclein Oligomerization and Age-Dependent Accumulation of 8–16-mer Oligomer Species." Cell Reports 29.9 (2019): 2862-2874.e9.

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